CHARACTERISTICS OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) IN HAITI
CHARACTERISTICS OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) IN HAITI
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DOI：
10.1056/nejm198310203091603
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
JOHNSON, WD
中科院分区：
文献类型：
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作者：
PAPE, JW;LIAUTAUD, B;JOHNSON, WD
为了确定海地发生的获得性免疫缺陷综合征(AIDS)的特征，我们研究了61名先前健康的海地人，他们在1979年6月至1982年10月期间在海地确诊为卡波西氏肉瘤(15例)、机会性感染(45例)或两者都有(1例)。海地的第一批卡波西肉瘤和机会性感染病例是在1978-1979年间发现的，这段时间与美国最早的艾滋病报告不谋而合。我们不认为海地在这一时期之前存在艾滋病。患有卡波西肉瘤和机会性感染的海地人的机会性感染类型和临床病程在大多数方面与美国的艾滋病患者相似。患有卡波西肉瘤和机会性感染的海地人的年龄中值为32岁，其中85%是男性。80%的患者从确诊到死亡的间隔时间为6个月。腹泻是机会性感染患者寻求医疗服务的最常见原因。86%的患者出现淋巴细胞减少，100%的患者出现皮试无能。在17%的男性患者和22%的女性患者中发现了潜在的危险因素(双性活动或输血)。人口统计信息表明，患者属于海地社会的所有社会经济阶层。《英国医学杂志》1983；309：945-50。
To identify the characteristics of the acquired immunodeficiency syndrome (AIDS) as it occurs in Haiti, we studied 61 previously healthy Haitians who had diagnoses of either Kaposi's sarcoma (15), opportunistic infections (45), or both (1) established in Haiti between June 1979 and October 1982. The first cases of Kaposi's sarcoma and opportunistic infections in Haiti were recognized in 1978–1979, a period that coincides with the earliest reports of AIDS in the United States. We do not believe that AIDS existed in Haiti before this period. The types of opportunistic infections and the clinical course in Haitians with Kaposi's sarcoma and opportunistic infections were similar in most aspects to those in patients with AIDS in the United States. The median age of Haitians with Kaposi's sarcoma and opportunistic infections was 32 years, and 85 per cent were men. The interval between diagnosis and death was six months in 80 per cent of the patients. Diarrhea was the most common reason for seeking medical attention in patients with opportunistic infections. Lymphopenia and skin-test anergy were observed in 86 and 100 per cent of patients, respectively. Potential risk factors (bisexual activity or blood transfusions) were identified in 17 per cent of male and 22 per cent of female patients. Demographic information suggests that patients belonged to all socioeconomic strata of Haitian society. (N Engl J Med 1983; 309:945–50.)