And the dead shall rise: actin and myosin return to the spindle.
And the dead shall rise: actin and myosin return to the spindle.
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DOI:
10.1016/j.devcel.2011.07.018
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发表时间:
2011-09-13
影响因子:
11.8
通讯作者:
Bement, William M.
中科院分区:
文献类型:
--
作者:
Sandquist, Joshua C.;Kita, Angela M.;Bement, William M.
The spindle directs chromosome partitioning in eukaryotes and, for the last three decades, has been considered primarily a structure based on microtubules, microtubule motors, and other microtubule binding proteins. However, a surprisingly large body of both old and new studies suggests roles for actin filaments (F-actin) and myosins (F-actin-based motor proteins) in spindle assembly and function. Here we review these data, and conclude that in several cases the evidence for F-actin and myosins participation in spindle function is very strong, and in the situations where it is less strong, there is nevertheless enough evidence to warrant further investigation.
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