And the dead shall rise: actin and myosin return to the spindle.

And the dead shall rise: actin and myosin return to the spindle.
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DOI:
10.1016/j.devcel.2011.07.018
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发表时间:
2011-09-13
期刊:
影响因子:
11.8
通讯作者:
Bement, William M.
Bement, William M.
中科院分区:
生物学1区
文献类型:
--
作者:
Sandquist, Joshua C.;Kita, Angela M.;Bement, William M.

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纺锤体在真核生物中指导染色体分配,并且在过去的三十年中,主要被认为是基于微管、微管马达和其他微管结合蛋白的结构。然而,令人惊讶的是,大量的新旧研究表明肌动蛋白丝(F-肌动蛋白)和肌球蛋白(F-肌动蛋白为基础的马达蛋白)在纺锤体组装和功能中的作用。在这里,我们回顾这些数据,并得出结论,在一些情况下,F-肌动蛋白和肌球蛋白参与纺锤体功能的证据是非常强大的,在它不太强大的情况下,仍然有足够的证据,值得进一步调查。
The spindle directs chromosome partitioning in eukaryotes and, for the last three decades, has been considered primarily a structure based on microtubules, microtubule motors, and other microtubule binding proteins. However, a surprisingly large body of both old and new studies suggests roles for actin filaments (F-actin) and myosins (F-actin-based motor proteins) in spindle assembly and function. Here we review these data, and conclude that in several cases the evidence for F-actin and myosins participation in spindle function is very strong, and in the situations where it is less strong, there is nevertheless enough evidence to warrant further investigation.
肌球蛋白在细胞质,裂解沟和人类细胞有丝分裂纺锤体中的荧光抗体定位。
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