Autoradiographic Demonstration of Increased α2‐Adrenoceptor Agonist Binding Sites in the Hippocampus and Frontal Cortex of Depressed Suicide Victims
Autoradiographic Demonstration of Increased α2‐Adrenoceptor Agonist Binding Sites in the Hippocampus and Frontal Cortex of Depressed Suicide Victims
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放射自显影显示抑郁症自杀受害者海马和额叶皮层 α2-肾上腺素受体激动剂结合位点增加
作者：
Antonio M. González;J. Pascual;J. Meana;F. Barturen;C. del Arco;Á. Pazos;J. García
摘要：为了在脑内直接检测α-2受体在重度抑郁症中的状态，用定量受体放射自显影技术测定了17例有抑郁症或其他精神障碍的自杀患者(n=17)和9例匹配的对照组(n=9)海马区和额叶皮质中激动剂[~3H]UK 14304的特异性结合。与对照组相比，自杀组大鼠海马CA1区(40%)和齿状回(20%)以及额叶皮质外层I(33%)和II(31%)的α-2受体数量显著增加。在抑郁的自杀受害者中，CA1区α-2-肾上腺素受体的增加(57%)显著高于有其他诊断的自杀受害者组(26%)。在相同的抑郁症自杀患者中，皮质α2-肾上腺素能受体的增加仅限于第I层(34%)，与有其他诊断的自杀患者第I层(33%)的增加相当。结果表明，自杀与脑α-2肾上腺素受体高亲和力状态的增加有关，抑郁症自杀者海马区的这种抑制性受体有明显的局部性增加。
Abstract: To examine directly in the brain the status of α2‐adrenoceptors in major depression, the specific binding of the agonist [3H]UK 14304 was measured by quantitative receptor autoradiography in the hippocampus and frontal cortex of suicide victims (n = 17) with a retrospective diagnosis of depression (n = 7) or other psychiatric disorders (n = 10) as well as of matched control subjects (n = 9). In suicide victims, a significant increase in the number of α2‐adrenoceptors was found in the CA1 field (40%) and dentate gyrus (20%) of the hippocampus and in the external layers I (33%) and II (31%) of the frontal cortex, compared with that in matched controls. In depressed suicide victims, the increase in α2‐adrenoceptors in the CA1 field (57%) was significantly greater (24%, p < 0.05) than that observed in the group of suicide victims with other diagnoses (26%). In the same depressed suicide victims, the increase in cortical α2‐adrenoceptors was restricted to layer I (34%) and it was equivalent to that found in layer I (33%) of suicide victims with other diagnoses. The results indicate that suicide is associated with increases in the high‐affinity state of brain α2‐adrenoceptors and that there is a pronounced localized increase of this inhibitory receptor in the hippocampus of depressed suicide victims.
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DOI：
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发表时间：
1988
期刊：
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