UNIFIED STEREOCHEMICAL MODEL OF POLYETHER ANTIBIOTIC-STRUCTURE AND BIOGENESIS
UNIFIED STEREOCHEMICAL MODEL OF POLYETHER ANTIBIOTIC-STRUCTURE AND BIOGENESIS
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DOI：
10.1021/ja00349a040
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发表时间：
1983-01-01
影响因子：
15
通讯作者：
WESTLEY, JW
中科院分区：
文献类型：
--
作者：
CANE, DE;CELMER, WD;WESTLEY, JW
提出了一个统一的立体化学模型，它与大量的聚醚类抗生素的结构和立体化学相关，并表明这种结构规律性的生物合成[放线菌]基础。两个立体化学原型总结了乙酸酯-丙酸酯-丙酸酯-乙酸酯和丙酸酯-乙酸酯-丙酸酯-乙酸酯结构家族的> 30种聚醚抗生素的立体化学模式。
A unified stereochemical model is proposed which correlates the structure and stereochemistry of a large number of polyether antibiotics and which suggests the biosynthetic [actinomycete] basis for this perceived structural regularity. Two stereochemical prototypes summarize the stereochemical patterns of > 30 polyether antibiotics of the acetate-propionate-propionate-acetate and propionate-acetate-propionate-acetate structural families.