Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization.

Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization.
复制标题

相同基因,相反性别:脊椎动物受精所需基因的性别特异性差异表达。

DOI:
10.1073/pnas.2116001118
复制
发表时间:
2021-10-19
影响因子:
11.1
通讯作者:
Bianchi E
Bianchi E
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Bianchi E

文献摘要

参考文献

相似文献

绝大多数真核生物都是有性繁殖;每个物种都产生高度特化的细胞,这些细胞具有不同的形态和功能特征,这些特征取决于个体的遗传性别。男性精子(精子)通常是携带父亲基因组的运动细胞(1,2),而女性卵母细胞通常是一个大的不动细胞,储存母亲基因组以及受精后启动新生物体发育所需的所有分子(3)。有性生殖依赖于受精--精子和卵子融合并将遗传信息传递给下一代的过程,从而创造出多样化、遗传独特的生物体。此外,受精标志着配子作为个体细胞的生命的结束,并触发了旨在发展新个体的大量分子事件。(4)2006年,J.S.等人报告说,一种在脊椎动物中保守的细胞表面蛋白是受精所必需的,他们表明,它的表达分别限于小鼠和斑马鱼的雄性或雌性配子,因此,它的作用方式在哺乳动物和鱼类中不同。
The vast majority of eukaryotes reproduce sexually; each species generates highly specialized cells with distinct morphological and functional characteristics that differ depending on the individual’s genetic sex. The male spermatozoon (sperm) is generally a motile cell that bears the paternal genome (1, 2), while the female oocyte usually is a large, immotile cell that stores the maternal genome together with all the molecules required to initiate the development of the new organism after fertilization (3). Sexual reproduction relies on fertilization—the process whereby sperm and eggs fuse and pass the genetic information to the next generation, thereby creating diverse, genetically unique organisms. Furthermore, fertilization marks the end of the gametes’ lives as individual cells and triggers a plethora of molecular events aiming at the development of a new individual.In PNAS Fujihara et al.(4) report that a cellsurface protein conserved across vertebrates is required for fertilization, and they show that its expression is restricted to the male or to the female gametes in the mouse and zebrafish, respectively, and consequently that its mode of action differs in mammals and fish.
DOI: 10.3389/fcell.2021.619868
发表时间: 2021
影响因子: 5.5
作者:
Gupta SK
通讯作者: Gupta SK
DOI: 10.1073/pnas.2108777118
发表时间: 2021-09-28
影响因子: 11.1
作者:
Fujihara Y;Herberg S;Blaha A;Panser K;Kobayashi K;Larasati T;Novatchkova M;Theussl HC;Olszanska O;Ikawa M;Pauli A
通讯作者: Pauli A
DOI: 10.7554/elife.66313
发表时间: 2021-04-19
期刊: eLife
影响因子: 7.7
作者:
Inoue N;Hagihara Y;Wada I
通讯作者: Wada I
DOI: 10.1038/nature13203
发表时间: 2014-04-24
期刊: Nature
影响因子: 64.8
作者:
通讯作者: --
DOI: 10.1126/science.aat7113
发表时间: 2018-09-07
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Herberg S;Gert KR;Schleiffer A;Pauli A
通讯作者: Pauli A