Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization.
Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization.
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相同基因,相反性别:脊椎动物受精所需基因的性别特异性差异表达。
DOI:
10.1073/pnas.2116001118
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发表时间:
2021-10-19
影响因子:
11.1
通讯作者:
Bianchi E
中科院分区:
文献类型:
--
作者:
Bianchi E
The vast majority of eukaryotes reproduce sexually; each species generates highly specialized cells with distinct morphological and functional characteristics that differ depending on the individual’s genetic sex. The male spermatozoon (sperm) is generally a motile cell that bears the paternal genome (1, 2), while the female oocyte usually is a large, immotile cell that stores the maternal genome together with all the molecules required to initiate the development of the new organism after fertilization (3). Sexual reproduction relies on fertilization—the process whereby sperm and eggs fuse and pass the genetic information to the next generation, thereby creating diverse, genetically unique organisms. Furthermore, fertilization marks the end of the gametes’ lives as individual cells and triggers a plethora of molecular events aiming at the development of a new individual.In PNAS Fujihara et al.(4) report that a cellsurface protein conserved across vertebrates is required for fertilization, and they show that its expression is restricted to the male or to the female gametes in the mouse and zebrafish, respectively, and consequently that its mode of action differs in mammals and fish.
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影响因子:
5.5
作者:
Gupta SK
通讯作者:
Gupta SK
DOI:
10.1073/pnas.2108777118
发表时间:
2021-09-28
影响因子:
11.1
作者:
Fujihara Y;Herberg S;Blaha A;Panser K;Kobayashi K;Larasati T;Novatchkova M;Theussl HC;Olszanska O;Ikawa M;Pauli A
通讯作者:
Pauli A
影响因子:
7.7
作者:
Inoue N;Hagihara Y;Wada I
通讯作者:
Wada I
影响因子:
64.8
作者:
通讯作者:
--
DOI:
10.1126/science.aat7113
发表时间:
2018-09-07
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Herberg S;Gert KR;Schleiffer A;Pauli A
通讯作者:
Pauli A