Sensory convergence in the parieto-insular vestibular cortex.
Sensory convergence in the parieto-insular vestibular cortex.
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DOI：
10.1152/jn.00731.2013
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发表时间：
2014-06
影响因子：
2.5
通讯作者：
Michael E. Shinder;S. Newlands
中科院分区：
文献类型：
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作者：
Michael E. Shinder;S. Newlands
前庭信号遍布整个中枢神经系统，包括皮质，在那里它们可能扮演着与脑干不同的角色。关于顶叶岛前庭皮质（PIVC），一个具有显著前庭输入的皮质区域，人们知之甚少。恒河猴的PIVC在头部，身体和视觉目标旋转的组合过程中记录的神经活动。许多PIVC神经元的活动与头部在空间中的运动（前庭）、颈部的扭转（本体感受）和视觉目标的运动相关，但与眼球运动无关。PIVC神经元最常对一种以上的刺激作出反应，对组合运动的反应通常可以近似为对头部、颈部和目标运动的个体敏感性的组合。PIVC神经元的视觉，前庭和躯体敏感性的模式显示了一个连续的范围，一些细胞强烈响应一个或两个刺激方式，而其他细胞响应任何类型的运动等效。PIVC包含自我运动线索与外部视觉对象运动信息的多感觉会聚，使得神经元不代表任何一个感觉输入的特定变换。相反，PIVC神经元群体可以定义头部、身体和外部视觉对象在空间中以及相对于彼此的移动。这种自我和外部运动的比较与岛叶皮层与监控相关的功能一致，并解释了以前研究中许多不同的发现。
Vestibular signals are pervasive throughout the central nervous system, including the cortex, where they likely play different roles than they do in the better studied brainstem. Little is known about the parieto-insular vestibular cortex (PIVC), an area of the cortex with prominent vestibular inputs. Neural activity was recorded in the PIVC of rhesus macaques during combinations of head, body, and visual target rotations. Activity of many PIVC neurons was correlated with the motion of the head in space (vestibular), the twist of the neck (proprioceptive), and the motion of a visual target, but was not associated with eye movement. PIVC neurons responded most commonly to more than one stimulus, and responses to combined movements could often be approximated by a combination of the individual sensitivities to head, neck, and target motion. The pattern of visual, vestibular, and somatic sensitivities on PIVC neurons displayed a continuous range, with some cells strongly responding to one or two of the stimulus modalities while other cells responded to any type of motion equivalently. The PIVC contains multisensory convergence of self-motion cues with external visual object motion information, such that neurons do not represent a specific transformation of any one sensory input. Instead, the PIVC neuron population may define the movement of head, body, and external visual objects in space and relative to one another. This comparison of self and external movement is consistent with insular cortex functions related to monitoring and explains many disparate findings of previous studies.