Investigating the choriocapillaris and choroidal vasculature with new optical coherence tomography technologies
Investigating the choriocapillaris and choroidal vasculature with new optical coherence tomography technologies
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DOI：
10.1016/j.preteyeres.2015.10.002
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发表时间：
2016-05-01
影响因子：
17.8
通讯作者：
Duker, Jay S.
中科院分区：
文献类型：
--
作者：
Ferrara, Daniela;Waheed, Nadia K.;Duker, Jay S.
近年来，光学相干断层扫描（OCT）技术的进步显著提高了对脉络膜体内研究的知识体系。新的见解阐明了生理和病理条件下脉络膜毛细血管和脉络膜血管的形态学特征，表明脉络膜在许多后段疾病中起着关键作用。在这篇文章中，回顾了脉络膜的组织学特征，这是正确解释体内成像必须考虑的因素，然后全面讨论了当前最先进的OCT的基本原理，包括横断面OCT、面OCT和使用光谱域OCT和扫描源OCT技术的OCT血管造影。本文详细回顾了正常眼脉络膜的断层扫描特征，以及常见脉络膜视网膜疾病的相关发现，重点介绍了导致视力丧失的主要原因，如典型的早期和晚期黄斑变性、息肉样脉络膜血管病变、中枢性浆液性脉络膜视网膜病变、厚脉络膜谱系障碍、糖尿病性脉络膜病变和近视。(C) 2015 Elsevier Ltd.版权所有。
The body of knowledge of in vivo investigation of the choroid has been markedly enhanced by recent technological advances in optical coherence tomography (OCT). New insights elucidating the morphological features of the choriocapillaris and choroidal vasculature, in both physiological and pathological conditions, indicate that the choroid plays a pivotal role in many posterior segment diseases. In this article, a review of the histological characteristics of the choroid, which must be considered for the proper interpretation of in vivo imaging, is followed by a comprehensive discussion of fundamental principles of the current state-of-the-art in OCT, including cross-sectional OCT, en face OCT, and OCT angiography using both spectral domain OCT and swept source OCT technologies. A detailed review of the tomographic features of the choroid in the normal eye is followed by relevant findings in prevalent chorioretinal diseases, focusing on major causes of vision loss such as typical early and advanced age related macular degeneration, polypoidal choroidal vasculopathy, central serous chorioretinopathy, pachychoroid spectrum disorders, diabetic choroidopathy, and myopia. (C) 2015 Elsevier Ltd. All rights reserved.