Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
复制标题
作者：
染色质组织对于维持基因表达的正确调节和建立细胞身份至关重要。然而，在细胞分裂过程中，遗传物质的复制会导致染色质结构的整体混乱。在本文中，我们描述了新的科学突破，这些突破揭示了复制后染色质的性质以及促进其恢复的机制。此外，我们强调了这些染色质改变对基因表达控制的影响及其对关键生物过程的影响，例如细胞分化、细胞重编程或与细胞增殖相关的人类疾病，例如癌症。
Chromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthroughs that have revealed the nature of the post-replicative chromatin and the mechanisms that facilitate its restoration. Moreover, we highlight the implications of these chromatin alterations in gene expression control and their impact on key biological processes, such as cell differentiation, cell reprogramming or human diseases linked to cell proliferation, such as cancer.
登录
查看更多内容
影响因子：
14.9
作者：
Fennessy, Ross T.;Owen-Hughes, Tom
通讯作者：
Owen-Hughes, Tom
影响因子：
10.5
作者：
Alabert C;Barth TK;Reverón-Gómez N;Sidoli S;Schmidt A;Jensen ON;Imhof A;Groth A
通讯作者：
Groth A
影响因子：
8.8
作者：
Alabert, Constance;Loos, Carolin;Groth, Anja
通讯作者：
Groth, Anja
影响因子：
64.5
作者：
JACKSON, V;CHALKLEY, R
通讯作者：
CHALKLEY, R
影响因子：
4.5
作者：
Gylling, Helene M.;Gonzalez-Aguilera, Cristina;Lund, Anders H.
通讯作者：
Lund, Anders H.