The metabolic syndrome
The metabolic syndrome
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DOI：
10.1111/j.1467-3010.2004.00403.x
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发表时间：
2004-03
影响因子：
3.3
通讯作者：
A. P.
中科院分区：
文献类型：
--
作者：
A. P.
代谢综合征被描述为几种心血管疾病风险因素的“聚类”，即肥胖（特别是腹部肥胖）、血脂异常、胰岛素抵抗和高血压。在全球范围内，这一综合征的发病率正在以惊人的速度上升。治疗包括药物治疗、饮食和生活方式的改变。为了减少这种疾病的发病率，并尽量减少保健服务的费用，必须更加强调预防，并加强对保健专业人员和公众的教育，使他们了解饮食和锻炼对预防这种疾病的重要性。迫切需要研究阐明该综合征的分子机制，评估识别该疾病的预后生物标志物，并分离和评估潜在的治疗剂。OB-AGE和LIPGENE项目是欧盟资助的研究项目，旨在提高我们对这种综合征的理解（在整个身体、细胞和分子水平上），并评估膳食脂肪酸在预防/改善这种疾病方面的有效性。
Summary The metabolic syndrome has been described as a ‘clustering’ of several risk factors for cardiovascular disease, namely obesity (particularly abdominal obesity), dyslipidaemia, insulin resistance and hypertension. Globally, the incidence of this syndrome is rising at an alarming rate. Treatments involve pharmacological therapies and diet and lifestyle changes. In order to reduce the incidence of this disease, and to minimise costs to health services, increasing emphasis must be placed on prevention, and on the education of health professionals and the public regarding the importance of diet and exercise in preventing this disease. Research is urgently required to elucidate the molecular mechanisms underlying this syndrome, to evaluate prognostic biomarkers identifying this disease and to isolate and evaluate potential therapeutic agents. The OB-AGE and LIPGENE projects are European Union funded research projects which aim to enhance our understanding of this syndrome (at a whole body, cellular and molecular level) and to evaluate the effectiveness of dietary fatty acids in preventing/ameliorating this disease.