TOXICITY OF NON-DRUG-CONTAINING LIPOSOMES FOR CULTURED HUMAN-CELLS
TOXICITY OF NON-DRUG-CONTAINING LIPOSOMES FOR CULTURED HUMAN-CELLS
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DOI：
10.1016/0014-4827(87)90262-x
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发表时间：
1987-07-01
影响因子：
3.7
通讯作者：
LAZO, R
中科院分区：
文献类型：
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作者：
MAYHEW, E;ITO, M;LAZO, R
测定了不同组成和大小的非药物脂质体对9种肿瘤细胞系和1种正常细胞系增殖的影响。含硬脂胺和心磷脂的脂质体在200微米或更低的脂浓度下毒性(ID50)，而含磷脂酰甘油和磷脂酰丝氨酸的脂质体在130-3000微米的毒性范围内。磷脂酰胆碱或二棕榈酰磷脂酰胆碱在3000-4000微米的范围内无毒性。结果表明，不含药物的脂质体对培养的人细胞的毒性差异很大。如果要进行药物脂质体的人类给药，应仔细考虑脂质体本身可能产生的非特异性毒性。
The effects of non-drug-containing liposomes of different compositions and sizes on the proliferation of nine cancer-derived and one normal cultured human cell lines were determined. Stearylamine- and cardiolipin-containing liposomes were toxic (ID50) at 200 .mu.M liposomal lipid concentrations or less, whereas phosphatidylglycerol- and phosphatidylserine-containing liposomes were toxic in the range 130-3000 .mu.M. Phosphatidylcholine or dipalmitoylphosphatidylcholine liposomes were not toxic at 3000-4000 .mu.M. In general, small liposomes were more toxic than large ones. The results indicate that there are wide variations in toxicity of non-drug-containing liposomes for cultured human cells. The potential for nonspecific toxicity due to the liposomes themselves should be carefully considered if human administration of drug-containing liposomes is to be done.