Loss-offunction afleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila

Loss-offunction afleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila
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DOI:
10.1534/genetics.106.059253
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发表时间:
2006-08-01
期刊:
影响因子:
3.3
通讯作者:
Johansen, Kristen M.
Johansen, Kristen M.
中科院分区:
生物学2区
文献类型:
--
作者:
Lerach, Stephanie;Zhang, Weiguo;Johansen, Kristen M.

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在这篇文章中,我们表明,亚纯型的JIL-1组蛋白H3 S10激酶的功能丧失等位基因是强抑制剂的位置效应杂色(PEV)的w(m4)等位基因和缺乏JIL-1的活性可以抵消的影响,占主导地位的增强子E(var)2-1对PEV。
In this article we show that hypomorphic loss-of-function alleles of the JIL-1 histone H3S10 kinase are strong suppressors of position effect variegation (PEV) of the w(m4) allele and that lack of JIL-1 activity can counteract the effect of the dominant enhancer E(var)2-1 on PEV.