Gold-Catalyzed Reductive Transformation of Nitro Compounds Using Formic Acid: Mild, Efficient, and Versatile.
Gold-Catalyzed Reductive Transformation of Nitro Compounds Using Formic Acid: Mild, Efficient, and Versatile.
复制标题
DOI：
10.1002/cssc.201500869
复制
发表时间：
2015-09
期刊：
影响因子：
8.4
通讯作者：
Lei Yu;Qi Zhang;Shu‐Shuang Li;Jun Huang;Yongmei Liu;Heyong He;Yong Cao
中科院分区：
文献类型：
--
作者：
Lei Yu;Qi Zhang;Shu‐Shuang Li;Jun Huang;Yongmei Liu;Heyong He;Yong Cao
在现代合成化学中，开发新的高效催化系统以紧凑、灵活和靶向的方式将丰富的可再生原料转化为有价值的产品是非常重要的。在这里，我们描述了一套多功能的温和催化条件，利用单一的金基固体催化剂，使四种不同的和重要的胺衍生物（胺、甲酰胺、苯并咪唑和二甲基胺）的直接和无添加剂的制备，从现成的甲酸（FA）和硝基起始材料具有高水平的化学选择性。由于其作为完全可再生的氢载体和多功能的C1源的潜力，在可持续化学领域引起了相当大的兴趣，通过控制所使用的FA的化学计量学，可以以模块化的方式实现硝基化合物的原子和阶梯高效转化。
Developing new efficient catalytic systems to convert abundant and renewable feedstocks into valuable products in a compact, flexible, and target-specific manner is of high importance in modern synthetic chemistry. Here, we describe a versatile set of mild catalytic conditions utilizing a single gold-based solid catalyst that enables the direct and additive-free preparation of four distinct and important amine derivatives (amines, formamides, benzimidazoles, and dimethlyated amines) from readily available formic acid (FA) and nitro starting materials with high level of chemoselectivity. By controlling the stoichiometry of the employed FA, which has attracted considerable interest in the area of sustainable chemistry because of its potential as an entirely renewable hydrogen carrier and as a versatile C1 source, a facile atom- and step-efficient transformation of nitro compounds can be realized in a modular fashion.