Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics.
Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics.
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DOI：
10.3390/antibiotics10060701
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发表时间：
2021-06-11
期刊：
影响因子：
--
通讯作者：
Wei Y
中科院分区：
文献类型：
--
作者：
Alegun O;Pandeya A;Cui J;Ojo I;Wei Y
革兰氏阴性菌的细胞被膜结构是独特的，由两个脂质双层膜和夹在其间的水性周质空间组成。外膜构成了一个额外的屏障，以限制细胞和外部环境之间的分子交换。唐南电位是跨膜电位，是细胞膜选择性通透性的结果，在许多抗生素的透性中起着关键作用。在这篇综述中，我们讨论了影响唐南电位的强度的因素，包括渗透强度和pH值的外部媒体，被困在周质空间中的钙调蛋白调节的周质葡聚糖，和位移的细胞表面电荷。我们讨论的重点是唐南电位对选定抗生素（包括氟喹诺酮类、四环素类、β-内酰胺类和甲氧苄啶）细胞渗透性的影响。
The cell envelope structure of Gram-negative bacteria is unique, composed of two lipid bilayer membranes and an aqueous periplasmic space sandwiched in between. The outer membrane constitutes an extra barrier to limit the exchange of molecules between the cells and the exterior environment. Donnan potential is a membrane potential across the outer membrane, resulted from the selective permeability of the membrane, which plays a pivotal role in the permeability of many antibiotics. In this review, we discussed factors that affect the intensity of the Donnan potential, including the osmotic strength and pH of the external media, the osmoregulated periplasmic glucans trapped in the periplasmic space, and the displacement of cell surface charges. The focus of our discussion is the impact of Donnan potential on the cellular permeability of selected antibiotics including fluoroquinolones, tetracyclines, β-lactams, and trimethoprim.
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影响因子：
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