Catabolic Cytokine Expressions in Patients with Degenerative Disc Disease
Catabolic Cytokine Expressions in Patients with Degenerative Disc Disease
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DOI：
10.5137/1019-5149.jtn.3394-10.1
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发表时间：
2010-10-01
影响因子：
0.8
通讯作者：
Hanci, Murat
中科院分区：
文献类型：
--
作者：
Akyol, Sibel;Eraslan, Berna Senel;Hanci, Murat
目的：腰椎间盘退行性疾病（DDD）是一种常见的老年疾病，其特征是椎间盘及其相关结构发生进行性变化。多年来，人们一直在努力解释其病理生理机制。本研究的目的是提供细胞因子的配置文件，除了在腰椎DDD.MATERIAL和METHODS患者的人群中的淋巴细胞：26例患者的临床和放射学特征暗示腰椎DDD进行手术和14例尸检作为对照。在手术过程中获得患者椎间盘样本，而在尸检过程中从对照组中收集椎间盘材料。结果：与对照组相比，患者椎间盘标本中IL-1 β、IL-2、IL-4、IL-10、IL-12、TNF-α、CD 8、CD 56、CD 19和CD 40的水平显著升高。CD 3/CD 4、CD 2 5/CD 3、CD 2 5/CD 4、CD 19/CD 4呈正相关，CD 19/CD 3、CD 2 5/CD 19呈负相关。通过局部或全身应用使用特定的细胞因子可以逆转退行性过程。
AIM: Lumbar degenerative disc disease (DDD) is a common disease of advanced age characterized by progressive changes in the intervertebral disc and associated structures. There have been great efforts for years to explain its pathophysiological mechanism(s). This study aims to provide cytokine profile and in addition to the lymphocytes in a population of patients with lumbar DDD.MATERIAL and METHODS: Twenty-six patients whose clinical and radiological features were suggestive of lumbar DDD that underwent surgery and 14 autopsy cases as control were included. Patient disc samples were obtained during surgery whilst disc materials were collected during autopsy procedures from the controls. Major cytokines and lymphocytes were studied by using the flow cytometry method.RESULTS: Significantly higher levels in disc samples in relation to IL-1 beta, IL-2, IL-4, IL-10, IL-12, TNF-alpha, CD8, CD56, CD19, and CD40 were found in the patients compared to the controls. Positive correlations were shown between CD3/CD4, CD25/CD3, CD25/CD4, CD19/CD4 but negative correlations were shown between CD19/CD3 and CD25/CD19 in both groups.CONCLUSION: The findings suggest that both local inflammatory responses occur in lumbar DDD. Using specific cytokines either by local or systemic application may reverse the degenerative process.