CHILDHOOD WEIGHT AND GROWTH-RATE AS PREDICTORS OF ADULT MORTALITY
CHILDHOOD WEIGHT AND GROWTH-RATE AS PREDICTORS OF ADULT MORTALITY
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DOI：
10.1093/oxfordjournals.aje.a116486
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发表时间：
1992-07-15
影响因子：
5
通讯作者：
COMSTOCK, GW
中科院分区：
文献类型：
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作者：
NIETO, FJ;SZKLO, M;COMSTOCK, GW
在1933-1945年期间，在马里兰州的哈格斯敦测量了13,146名5 - 18岁的人的体重和身高，研究了儿童期生长速度和相对体重对成人死亡率的影响。内部定义相对体重，使用国家标准计算身高和体重的年龄和性别特异性Z评分，并以年增量测量身高和体重速度。在1985年之前，我们在符合以下条件的受试者中研究了生长参数（青春期前和青春期后）与死亡率之间的关系。1963年和1975年华盛顿县，马里兰州私人健康普查，采用巢式病例对照设计。死亡率的比值比随青春期前相对体重（两性合计p < 0.05）和女性青春期后相对体重（p < 0.01）线性增加。生长速度或达到的高度与死亡率之间的关联往往是相反的，虽然没有统计学意义。这些结果与学龄儿童超重与长期死亡率之间存在的正相关性是一致的，似乎减轻了人们对儿童期增长率增加可能带来危害的担忧。在不损害生长的情况下，避免儿童期超重可能会降低中年死亡率。
The effect of rate of growth and relative weight in childhood on adult mortality was studied among 13,146 persons whose weights and heights were measured between the ages of 5 and 18 years in Hagerstown, Maryland, during the period 1933-1945. Relative weight was defined internally, age- and sex-specific Z-scores for height and weight were calculated using national standards, and height and weight velocities were measured as annual increments. Associations between growth parameters (pre- and postpubertal) and mortality through 1985 were investigated in subjects who matched the. 1963 and 1975 private health censuses of Washington County, Maryland, using a nested case-control design. Odds ratios of mortality increased linearly with prepubertal relative weight (p < 0.05 for both sexes combined) and with postpubertal relative weight in females (p < 0.01). The associations between growth velocities or attained height with mortality tended to be inverse, although not statistically significant. These results are compatible with the existence of positive associations of overweight in school-age children with long-term mortality and seem to allay fears that harm could come from increased growth rates in childhood. Without jeopardizing growth, the avoidance of overweight in childhood might reduce mortality in middle age.