Diagnosis and treatment of Ewing sarcoma of the bone: a review article.
Diagnosis and treatment of Ewing sarcoma of the bone: a review article.
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DOI：
10.1007/s00776-014-0687-z
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发表时间：
2015-03
影响因子：
1.7
通讯作者：
Ozaki, Toshifumi
中科院分区：
文献类型：
--
作者：
Ozaki, Toshifumi
尤文肉瘤（ES）在日本人中很少见，每年只有30-40名患者患此病。诊断ES，分子技术，目的是检测特征融合基因，通常与传统的组织学和免疫组化检查相结合。ES的治疗策略的特点是儿科肿瘤学家、内科肿瘤学家、放射肿瘤学家和整形外科医生之间的多学科合作。近年来，许多大规模的国家或国际多机构的ES研究已经完成。术前和术后使用多种抗癌药物的强化全身化疗是ES的标准治疗方法。根据获得的手术切缘，也可能进行术后放疗。如果术前放射学检查表明手术切除有困难，可以进行术前放射治疗。随着ES治疗效果的改善，晚期并发症和继发性恶性肿瘤已成为一个问题。治疗后，ES患者需要非常长期的随访，以检测继发性恶性肿瘤和生长相关的肌肉骨骼并发症。
Ewing sarcoma (ES) is rare in Japanese people, and only 30–40 patients develop the disease annually. To diagnose ES, molecular techniques that aim to detect characteristic fusion genes are commonly used in combination with conventional histological and immunohistochemical examinations. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. In recent years, numerous large-scale national or international multi-institutional studies of ES have been performed. Pre- and postoperative intensive systemic chemotherapy with multiple anticancer drugs is the standard treatment method for ES. Depending on the obtained surgical margin, postoperative radiation might also be performed. If preoperative radiological examinations indicate that surgical excision would be difficult, preoperative radiation can be administered. As the treatment outcomes of ES have improved, late complications and secondary malignancies have become a problem. After treatment, patients with ES require very long-term follow-up in order to detect secondary malignancies and growth-related musculoskeletal complications.
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DOI：
10.1302/0301-620x.92b7.23497
发表时间：
2010-07-01
影响因子：
--
作者：
Akiyama, T.;Clark, J. C. M.;Choong, P. F. M.
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
5.6
作者：
HASHIMOTO, H;ENJOJI, M;DAIMARU, Y
通讯作者：
DAIMARU, Y
影响因子：
3.1
作者：
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通讯作者：
Juergens, Heribert