TLX: A master regulator for neural stem cell maintenance and neurogenesis.
TLX: A master regulator for neural stem cell maintenance and neurogenesis.
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DOI：
10.1016/j.bbagrm.2014.06.001
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Zhang CL
中科院分区：
文献类型：
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作者：
Islam MM;Zhang CL
孤儿核受体 TLX，也称为 NR2E1，是神经干细胞 (NSC) 自我更新、维持和神经发生的重要调节因子。在脊椎动物中，TLX 在整个发育和成年期专门定位于前脑和视网膜的神经源性区域。 TLX 调节参与多种途径的基因表达，例如细胞周期、DNA 复制和细胞粘附。这些作用主要是通过下游靶基因的转录抑制或激活来发挥的。新出现的证据表明，TLX 的失调可能在人类神经系统疾病的发生和进展中发挥作用，使该因素成为理想的治疗靶点。在这里，我们回顾了目前对 TLX 功能、表达、调节和活性的理解，这些功能、表达、调节和活性对 NSC 维持、成人神经发生和大脑可塑性具有重要意义。
The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is specifically localized to the neurogenic regions of the forebrain and retina throughout development and adulthood. TLX regulates the expression of genes involved in multiple pathways, such as the cell cycle, DNA replication, and cell adhesion. These roles are primarily performed through the transcriptional repression or activation of downstream target genes. Emerging evidence suggests the misregulation of TLX might play a role in the onset and progression of human neurological disorders making this factor an ideal therapeutic target. Here, we review the current understanding of TLX function, expression, regulation, and activity significant to NSC maintenance, adult neurogenesis, and brain plasticity.