Metabolic organization of the myelinating Schwann cell.
Metabolic organization of the myelinating Schwann cell.
复制标题
髓鞘雪旺细胞的代谢组织。
DOI：
10.1111/j.1749-6632.1990.tb42379.x
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发表时间：
1990
影响因子：
5.2
通讯作者：
Gould,RM
中科院分区：
文献类型：
--
作者：
Gould,RM
在周围神经系统（PNS）发育期间，雪旺细胞分隔较大的轴突并使其髓鞘化。髓鞘形成的形态学和生物化学研究都使用啮齿动物作为实验模型。发育中的大鼠坐骨神经的光学显微镜图像表明代谢驱动进入髓鞘形成（图1）。Friede、Samorajskil和Webster 2对啮齿动物PNS髓鞘形成的程度进行了定量。对于更大的神经纤维，髓鞘膜比其他神经膜（例如外部许旺细胞质膜和轴膜）长2,000倍。“整个”坐骨神经在发育过程中积累髓鞘蛋白和“髓鞘典型”脂质。(See Smith 3和Yao 4的评论。）髓磷脂蛋白基因的克隆为阐明这些蛋白的转录和翻译调控开辟了可能性（见Poduslo和Lemke，本卷）。本报告的目的是强调，这些监管活动，以及参与脂质代谢发生在髓鞘雪旺细胞胞质中的离散网站。
During peripheral nervous system (PNS) development, Schwann cells partition the larger axons and myelinate them. Both morphologic and biochemical studies of myelination have used rodents as experimental models. Light microscopic images of developing rat sciatic nerve suggest the metabolic drive funneled into myelination (FIG. 1). Friede and Samorajskil and Webster2 quantified the magnitude of rodent PNS myelination. For larger nerve fibers, myelin membranes grow up to 2,000 times more than do other neural membranes, for example, the external Schwann cell plasma membrane and the axolemma.'Whole'sciatic nerves accumulate myelin proteins and'myelin-typical'lipids during development.(See Smith3 and Yao4 for reviews.) The recent cloning of myelin protein genes has opened up possibilities for elucidating the transcriptional and translational regulation of these proteins (see Poduslo and Lemke, this volume). The goal of this presentation is to emphasize that these regulatory events as well as those involved in lipid metabolism occur at discreet sites in myelinating Schwann cell cytoplasm.