The contribution of the central nucleus of the amygdala to individual differences in amphetamine-induced hyperactivity.
The contribution of the central nucleus of the amygdala to individual differences in amphetamine-induced hyperactivity.
复制标题
杏仁核中央核对安非他明引起的多动症个体差异的贡献。
DOI：
10.1016/j.bbr.2009.03.007
复制
发表时间：
2009
影响因子：
2.7
通讯作者：
Gill,MargaretJ
中科院分区：
文献类型：
--
作者：
Cain,MaryE;Coolon,RosemaryA;Gill,MargaretJ
大鼠归类为高反应（HR）的基础上，他们的反应，一个不可避免的新的环境自我管理更多的安非他明，并有更大的安非他明诱导的致敏性比大鼠归类为低反应（LR）。最近的研究表明，杏仁中央核（ACe）有助于提高HR大鼠的自我管理。因此，本研究探讨了ACe在苯丙胺诱导的致敏和条件性多动的HR和LR大鼠的表达中的作用。筛选雄性Sprague-Dawley大鼠对不可避免的新奇事物的反应，并将其分类为HR或LR大鼠。将双侧插管植入大鼠ACe中，并接受安非他明（1.0mg/kg，s.c.）或在1小时运动期之前立即注射盐水。在5次训练后，所有大鼠接受蝇蕈醇（0.5μg/0.5μl）或磷酸盐缓冲盐水（PBS）输注，然后注射盐水以测量条件性多动症。HR大鼠表现出条件性多动，而LR大鼠没有，这表明HR和LR大鼠在条件性多动的表达上存在差异。虽然ACe失活减弱了条件性多动的表达，但对HR和LR大鼠的影响没有差异。在额外的训练和10天的休息期后，所有大鼠在输注蝇蕈醇或PBS后测试安非他明诱导的致敏性（1.0mg/kg）。ACe的失活只在HR大鼠中减弱了致敏的表达。这些结果表明，ACe有助于更大的安非他明致敏在HR大鼠。
Rats classified as high responders (HR) based on their response to an inescapable novel environment self-administer more amphetamine and have greater amphetamine-induced sensitization than rats classified as low responders (LR). Recent research suggests that the central nucleus of the amygdala (ACe) contributes to the elevated self-administration in HR rats. Therefore, the current study examined the role of the ACe in the expression of both amphetamine-induced sensitization and conditioned hyperactivity in HR and LR rats. Male Sprague–Dawley rats were screened for their response to inescapable novelty and classified as HR or LR rats. Rats were implanted with bilateral cannulae into the ACe and received amphetamine (1.0mg/kg, s.c.) or saline injections immediately prior to 1-h locomotor sessions. Following five training sessions, all rats received an infusion of muscimol (0.5μg/0.5μl) or phosphate buffered saline (PBS) followed by a saline injection to measure conditioned hyperactivity. HR rats displayed conditioned hyperactivity, while LR rats did not, suggesting that HR and LR rats differ in the expression of conditioned hyperactivity. While ACe inactivation attenuated the expression of conditioned hyperactivity, it did not differentially affect HR and LR rats. Following additional training and a 10-day rest period, all rats were then tested for amphetamine-induced sensitization (1.0mg/kg) following an infusion of muscimol or PBS. Inactivation of the ACe attenuated the expression of sensitization only in HR rats. These results suggest the ACe contributes to the greater amphetamine sensitization in HR rats.