CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy.
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy.
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DOI：
10.1212/nxi.0000000000000138
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Kaji R
中科院分区：
文献类型：
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作者：
Furukawa T;Matsui N;Fujita K;Nodera H;Shimizu F;Miyamoto K;Takahashi Y;Kanda T;Kusunoki S;Izumi Y;Kaji R
我们旨在比较多灶性运动神经病（MMN）患者与进行性肌萎缩（PMA）和肌萎缩侧索硬化（ALS）患者的细胞因子和趋化因子谱，以研究CNS中的免疫学差异。使用多重微珠阵列分析法分析了12例MMN患者、8例PMA患者、26例散发性ALS患者和10例其他非炎性神经系统疾病患者的CSF中的27种细胞因子和趋化因子。比较4组细胞因子滴度，并评价相关细胞因子滴度与临床指标的相关性。MMN患者鞘内除IL-1受体拮抗剂外无明显变化。相比之下，PMA和ALS患者的IL-4、IL-7、IL-17、嗜酸性粒细胞趋化因子/CCL 11、成纤维细胞生长因子-2（FGF-2）、粒细胞集落刺激因子（G-CSF）和血小板源性生长因子BB滴度显著升高;其中，FGF-2和G-CSF滴度与MMN患者相比升高。IL-4和IL-10滴度在ALS患者中较高，特别是表现出缓慢进展过程或轻度症状的可能ALS患者。MMN患者的CSF细胞因子谱与PMA和ALS患者不同。PMA和ALS患者之间细胞因子谱的相似性表明，即使没有上运动神经元受累的临床证据，PMA也与CNS中的ALS具有共同的免疫学特征。
We aimed to compare the cytokine and chemokine profiles of patients with multifocal motor neuropathy (MMN) with those of patients with progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) to investigate immunologic differences in the CNS. CSF from 12 patients with MMN, 8 with PMA, 26 with sporadic ALS, and 10 with other noninflammatory neurologic disorders was analyzed for 27 cytokines and chemokines using the multiplex bead array assay. Cytokine titers of the 4 groups were compared, and correlations between the titers of relevant cytokines and clinical parameters were evaluated. There were no obvious intrathecal changes except for interleukin (IL)-1 receptor antagonist in patients with MMN. In contrast, IL-4, IL-7, IL-17, eotaxin/CCL11, fibroblast growth factor-2 (FGF-2), granulocyte colony-stimulating factor (G-CSF), and platelet-derived growth factor BB titers were significantly elevated in patients with PMA and ALS; of these, FGF-2 and G-CSF titers were elevated compared with those in patients with MMN. IL-4 and IL-10 titers were high in patients with ALS, particularly patients with possible ALS presenting with a slowly progressive course or mild symptoms. The CSF cytokine profile of patients with MMN is distinct from that of patients with PMA and ALS. The similarity of the cytokine profiles between patients with PMA and ALS suggests that PMA shares common immunologic features with ALS in the CNS, even without clinical evidence of upper motor neuron involvement.