Longitudinal vasculature changes in branch retinal vein occlusion with projection-resolved optical coherence tomography angiography
Longitudinal vasculature changes in branch retinal vein occlusion with projection-resolved optical coherence tomography angiography
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DOI：
10.1007/s00417-019-04371-6
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发表时间：
2019-09-01
影响因子：
2.7
通讯作者：
Kamei, Motohiro
中科院分区：
文献类型：
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作者：
Tsuboi, Kotaro;Kamei, Motohiro
目的应用投影分辨光学相干断层扫描血管成像（PR-OCTA）分析视网膜分支静脉阻塞（BRVO）的血管改变。方法回顾性分析30例30眼BRVO患者的临床资料。PR-OCTA在急性期、中期和缓解期进行，此时抗血管内皮生长因子药物抑制囊性变化。主要的观察指标为浅表毛细血管丛（SCP）、中间毛细血管丛（ICP）和深毛细血管丛（DCP）的血管密度（VD）和视网膜厚度变化。结果随访期间SCP和DCP的VD无纵向变化。ICP缓解期的VD显著（p = 0.0105）大于急性期。在随访期间，全视网膜厚度（内界膜[ILM]至视网膜色素上皮[RPE]）和视网膜内层厚度（ILM至内丛状层[IPL]）显著降低（分别为p = 0.0002和p = 0.0014）。当内层视网膜薄于117 μ m时，在随访期间ICP中的VD显著增加（p = 0.045）。当视网膜内层没有变薄时，ICP中的VD保持不变。结论PR-OCTA显示了BRVO的3个不同的血管丛。SCP和DCP的VD在随访期间保持不变，但ICP在缓解期间显著增加。尽管使用PR-OCTA，但由于投影伪影和分割错误，内部视网膜变薄可能会导致ICP中VD的增加。
Purpose To analyze vascular changes in branch retinal vein occlusion (BRVO) using projection-resolved optical coherence tomography angiography (PR-OCTA). Methods We reviewed 30 consecutive eyes of 30 cases with BRVO retrospectively. PR-OCTA was performed during the acute, intermediate, and remission phases when anti-vascular endothelial growth factor drugs suppress cystic changes. The main outcome measures were vessel density (VD) and retinal thickness changes in the superficial capillary plexus (SCP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Results The VDs did not change longitudinally in the SCP and DCP during the follow-up period. The VD was significantly (p = 0.0105) greater in the ICP during remission than the acute phase. The full retinal thickness (internal limiting membrane [ILM] to retinal pigment epithelium [RPE]) and inner retinal thickness (ILM to inner plexiform layer [IPL]) decreased significantly (p = 0.0002 and p = 0.0014, respectively) during the follow-up period. When the inner retina was thinner than 117 mu m, the VD in the ICP increased significantly (p = 0.045) during the follow-up period. When the inner retinal layer did not become thinner, the VD in the ICP remained unchanged. Conclusion PR-OCTA showed the three distinct vascular plexuses in BRVO. The VDs remained unchanged during the follow-up period in the SCP and DCP but increased significantly in the ICP during remission. Inner retinal thinning might cause increases in the VD in the ICP because of projection artifacts and segmentation errors despite using PR-OCTA.