Incidence of intracranial tumours in the Lothian region of Scotland, 1989-90
Incidence of intracranial tumours in the Lothian region of Scotland, 1989-90
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DOI：
10.1136/jnnp.61.2.143
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发表时间：
1996-08-01
影响因子：
11
通讯作者：
Grant, R
中科院分区：
文献类型：
--
作者：
Counsell, CE;Collie, DA;Grant, R
目的-确定苏格兰东南部洛锡安地区原发和继发性颅内肿瘤的发病率。对1989年和1990年(通过CT或组织学)诊断为颅内肿瘤的洛锡安患者进行了多种来源的回顾性鉴定。分析不同肿瘤类型、年龄、性别和社会经济状况的发病率差异。结果：442例颅内肿瘤患者中，原发肿瘤2 2 8例，继发肿瘤2 14例。原发肿瘤和继发性肿瘤的年粗略发病率分别为15.3/10万和14.3/10万。最常见的原发肿瘤是神经上皮性肿瘤(53.5%)、脑膜瘤(19.5%)和鞍区肿瘤(16.5%)。大约50%的继发性肿瘤患者有潜在的肺癌。原发肿瘤和继发肿瘤的发病率随着年龄的增长而显著增加。脑膜肿瘤在女性中更常见，神经上皮肿瘤在生活在更富裕地区的人中更常见。结论--洛锡安的原发和继发性颅内肿瘤的发病率是英国以前报告的两倍以上。在英国，颅内肿瘤是发病率和死亡率的重要原因，迫切需要对其病因和治疗进行进一步研究。
Objective-To determine the incidence of primary and secondary intracranial tumours in the Lothian region of south east Scotland.Methods-A population based study was performed. Patients from Lothian with incident intracranial tumours diagnosed in 1989 and 1990 (by CT or histology) were identified retrospectively using multiple sources. Differences in incidence by tumour type, age, sex, and socioeconomic status were examined.Results-Four hundred and forty two patients with incident intracranial tumours were identified (228 primary tumours and 214 secondary tumours). The crude yearly incidences of primary and secondary tumours were 15.3 and 14.3 per 100 000 respectively. The commonest primary tumours were neuroepithelial tumours (53.5%), meningeal tumours (19.5%), and sellar tumours (16.5%). About 50% of patients with secondary tumours had an underlying lung cancer. The incidence of primary and secondary tumours increased markedly with age. Meningeal tumours were more common in women, and neuroepithelial tumours were more common in those who lived in more affluent areas.Conclusions-The incidence rates of primary and secondary intracranial tumours in Lothian were more than twice those previously reported in the United Kingdom. Intracranial tumours are a significant cause of morbidity and mortality in the United Kingdom, and further research into their aetiology and treatment is urgently required.