Lumpy skin disease: Preliminary vaccine efficacy assessment and overview on outbreak impact in dairy cattle at Debre Zeit, central Ethiopia
Lumpy skin disease: Preliminary vaccine efficacy assessment and overview on outbreak impact in dairy cattle at Debre Zeit, central Ethiopia
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DOI：
10.1016/j.antiviral.2013.02.008
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发表时间：
2013-05-01
影响因子：
7.6
通讯作者：
Asmare, Kassahun
中科院分区：
文献类型：
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作者：
Ayelet, Gelagay;Abate, Yebeyen;Asmare, Kassahun
这项研究是在 Debre Zeit 镇及其周边地区进行的，旨在评估 LSD 疫苗的使用效果并概述相关疾病的影响。该研究包括横断面和回顾性研究设计，采用主动疾病随访、半结构化问卷调查和分子技术。研究结果显示，用于控制 LSD 的肯尼亚羊痘疫苗株并未提供预期的保护作用。在观察的 476 头牛中，分别有 22.9% 和 2.31% 的牛因 LSD 而患病和死亡。荷斯坦瘤牛杂交品种的特定发病率为 22.5%，当地瘤牛品种的特定发病率为 25.9%。据观察，这种疾病在幼年动物和雌性动物中更为严重。其发生也呈现出季节性趋势。该研究结果敦促需要对疫苗失败进行调查，包括疫苗匹配和替代疫苗开发。 (C) 2013 年由 Elsevier B.V. 出版
This study was conducted in and around Debre Zeit town to assess the field efficacy of LSD vaccine in use and overview associated disease impact. The study comprised cross-sectional and retrospective study design which employed active disease follow-up, semi-structured questionnaire survey and molecular techniques. The finding revealed that the Kenyan sheep pox vaccine strain used for the control of LSD did not confer expected protection. From the total of 476 animals observed, 22.9% and 2.31% cattle were found sick and dead due to LSD, respectively. Breed specific morbidity rate was 22.5% in Holstein Friesian-zebu cross and 25.9% in local zebu breed. The disease was observed to be more serious in young animals and also in females. A trend of seasonality was also observed in its occurrence. The study finding urges the need for investigation of vaccine failure including vaccine matching and alternative vaccine development. (C) 2013 Published by Elsevier B.V.