Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults
Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults
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DOI：
10.2337/diacare.27.6.1375
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发表时间：
2004-06-01
期刊：
影响因子：
16.2
通讯作者：
Cummings, SR
中科院分区：
文献类型：
--
作者：
Kanaya, AM;Harris, T;Cummings, SR
目的 - 检查脂联素是否与糖尿病独立相关，以及脂联素和其他脂肪细胞因子是否解释脂肪与糖尿病之间的关系。 研究设计和方法 - 来自健康、衰老和身体成分 (Health ABC) 研究的嵌套病例对照研究。我们测量了四种脂肪细胞因子：脂联素、白介素（IL）-6、肿瘤坏死因子-a和纤溶酶原激活剂抑制剂1（PA1-1）。通过计算机断层扫描确定区域脂肪面积。 519 名受试者患有糖尿病，定义为空腹血糖水平大于或等于 126 mg/dl 或使用糖尿病药物。 519 名对照受试者具有正常的葡萄糖耐量，并且按性别、种族和研究地点进行匹配。性别特异性逻辑模型根据年龄、种族、部位、总肥胖、吸烟和体力活动进行调整。结果-较高的脂联素水平与较低的糖尿病风险相关（P < 0.001）。调整 BMI 后，内脏脂肪是唯一与糖尿病相关的肥胖指标（女性比值比为 3.0 [2.1-4.3]，男性为 1.3 [1.0-1.6]，性别间比较 P < 0.001）。脂肪细胞因子减弱了两性内脏脂肪与糖尿病之间的关联，但在男性中更为强烈（女性 2.3 [1.5-3.3]，男性 1.1 [0.9-1.4]）。在男性中，脂联素、IL-6 和 PAI-1 在调整脂肪库后仍然与糖尿病独立相关。在女性中，脂联素是唯一独立相关的脂肪细胞因子。控制胰岛素、高密度脂蛋白、甘油三酯和血压并没有改变这些结果。结论——脂联素与老年男性和女性患糖尿病的几率较低有关。虽然多种脂肪细胞因子解释了男性内脏肥胖与糖尿病之间的关系，但只有脂联素部分介导了女性的这种关联。
OBJECTIVE - To examine whether adiponectin is independently associated with diabetes and whether adiponectin and other adipocytokines account for the relationship between fat and diabetes.RESEARCH DESIGN AND METHODS - A nested case-control study from the Health, Aging, and Body Composition (Health ABC) Study. We measured four adipocytokines: adiponectin, interleukin (IL)-6, tumor necrosis factor-a, and plasminogen activator inhibitor 1 (PAl-1). Regional fat area was determined by computed tomography scan. The 519 case subjects had diabetes defined by fasting plasma glucose level greater than or equal to126 mg/dl or by use of diabetes medications. The 519 control subjects had normal glucose tolerance and were matched by sex, race, and study site. Sex-specific logistic models were adjusted for age, race, site, total adiposity, smoking, and physical activity.RESULTS- Higher adiponectin levels were associated with lower risk of diabetes (P < 0.001). Visceral fat was the only adiposity measure associated with diabetes after adjusting for BMI (odds ratio 3.0 [2.1-4.3] in women and 1.3 [1.0-1.6] in men, P < 0.001 between-sex comparison). Adipocytokines attenuated the association between visceral fat and diabetes for both sexes but more strongly in men (women 2.3 [1.5-3.3], men 1.1 [0.9-1.4]). In men, adiponectin, IL-6, and PAI-1 remained independently associated with diabetes after adjusting for fat depots; in women, adiponectin was the only independently associated adipocytokine. Controlling for insulin, HDL, triglycerides, and blood pressure did not change these results.CONCLUSIONS - Adiponectin is associated with lower odds of diabetes in older men and women. Whereas several adipocytokines explained the relationship between visceral adiposity and diabetes in men, only adiponectin partially mediated this association among women.