Do Discrete Choice Experiments Approaches Perform Better Than Time Trade-Off in Eliciting Health State Utilities? Evidence From SF-6Dv2 in China.
Do Discrete Choice Experiments Approaches Perform Better Than Time Trade-Off in Eliciting Health State Utilities? Evidence From SF-6Dv2 in China.
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DOI：
10.1016/j.jval.2020.06.010
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发表时间：
2020-09
期刊：
影响因子：
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通讯作者：
S. Xie;Jing Wu;Xiaoning He;Gang Chen;J. Brazier
中科院分区：
文献类型：
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作者：
S. Xie;Jing Wu;Xiaoning He;Gang Chen;J. Brazier
目的探讨离散选择实验（discrete choice experiment，DCE）和生命持续维度（life duration dimension，DCETTO）与SF-6Dv 2的时间权衡（time trade-off，TTO）在健康状态效用价值评估中的可接受性、一致性和准确性。TTO和DCE/DCETO的顺序是随机的。固定效应模型和条件logit模型分别用于TTO和DCE数据估计。通过自我报告的理解/回答困难评估可接受性。通过模型系数的单调性观察到一致性。通过使用组内相关系数、平均绝对差和均方根差调查观察到的TTO值和预测的TTO值之间的差异来评估准确性。结果共纳入503名受访者（53.7%男性;范围，18-86岁），完成VCE（N = 252）和DCETTO（N = 251）的受访者之间具有可比性。3种方法的自我报告困难无显著差异。系数的单调性不能实现的2 DCE方法，即使当结合不一致的水平。由DCE产生的健康状态效用值通常高于由TTO产生的健康状态效用值，而DCERTO低于TTO。TTO有一个更好的预测准确性比DCEs.ConclusionsTwo DCE方法是可行的健康状态的效用值，但是，他们不被认为是更容易理解/回答比TTO。3种方法产生的健康状态效用值存在系统性差异。来自2DCE方法的非单调性问题仍然是一个问题。
ObjectivesTo explore the acceptability, consistency, and accuracy of eliciting health state utility values using discrete choice experiment (DCE) and DCE with life duration dimension (DCETTO) as compared with conventional time trade-off (TTO) by using the SF-6Dv2.MethodsDuring face-to-face interviews, a representative sample of the general population in Tianjin, China, completed 8 TTO tasks and 10 DCE/DCETTOtasks, with the order of TTO and DCE/DCETTObeing randomized. The fixed-effect model and conditional logit models were used for TTO and DCEs data estimation, respectively. Acceptability was assessed by self-reported difficulties in understanding/answering. Consistency was observed by the monotonicity of model coefficients. Accuracy was evaluated by investigating differences between observed and predicted TTO values using intraclass correlation coefficient, mean absolute difference, and root mean square difference.ResultsA total of 503 respondents (53.7% male; range, 18-86 years) were included, with comparable characteristics between respondents who completed DCE (N = 252) and DCETTO(N = 251). No significant difference was observed in self-reported difficulties among 3 approaches. The monotonicity of coefficients could not be achieved for 2 DCE approaches, even when combining the inconsistent levels. The health state utility values generated by DCE were generally higher than those generated by TTO, whereas DCETTOwas lower than TTO. The TTO had a better prediction accuracy than the DCEs.ConclusionsTwo DCE approaches are feasible for eliciting health state utility values; however, they are not considered to be easier to understand/answer than TTO. There are systematic differences in the health state utility values generated by 3 approaches. The issue of non-monotonicity from 2 DCE approaches remains a concern.