Molecular Mechanisms of Lysosome and Nucleus Communication.
Molecular Mechanisms of Lysosome and Nucleus Communication.
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DOI：
10.1016/j.tibs.2020.06.004
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发表时间：
2020-11
影响因子：
13.8
通讯作者：
Wang MC
中科院分区：
文献类型：
--
作者：
Zhao Q;Gao SM;Wang MC
溶酶体超越了降解站的角色，充当细胞器间串扰和信号转导的关键节点。溶酶体通过物理接近和功能相互作用与细胞核通信。为了响应外部和内部刺激，溶酶体主动调节其在外周和核周区域之间的分布，并调节溶酶体到核的信号传导途径，而核反过来通过转录控制微调溶酶体的生物发生和功能。这两种基本细胞器之间协调的变化与代谢紊乱、神经退行性疾病和衰老有关。本文综述了溶酶体和细胞核通讯的多层次调控机制的最新进展，并讨论了这些调控如何耦合代谢输入与细胞器运动，细胞信号和转录网络。
Lysosomes transcend the role of degradation stations, acting as key nodes to inter-organelle crosstalk and signal transduction. Lysosomes communicate with the nucleus through physical proximity and functional interaction. In response to external and internal stimuli, lysosomes actively adjust their distribution between peripheral and perinuclear regions and modulate lysosome-to-nucleus signaling pathways, and the nucleus in turn fine-tunes lysosomal biogenesis and functions through transcriptional controls. Changes in coordination between these two essential organelles are associated with metabolic disorders, neurodegenerative diseases, and aging. This review addresses recent advances in lysosome-and-nucleus communication by multi-tiered regulatory mechanisms and discusses how these regulations couple metabolic inputs with organellar motility, cellular signaling, and transcriptional network.
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影响因子：
16.6
作者：
Dong, Xian-ping;Shen, Dongbiao;Wang, Xiang;Dawson, Taylor;Li, Xinran;Zhang, Qi;Cheng, Xiping;Zhang, Yanling;Weisman, Lois S.;Delling, Markus;Xu, Haoxing
通讯作者：
Xu, Haoxing
影响因子：
56.9
作者：
CHIANG, HL;TERLECKY, SR;DICE, JF
通讯作者：
DICE, JF
影响因子：
64.8
作者：
Fu, J;Gaetani, S;Piomelli, D
通讯作者：
Piomelli, D
影响因子：
4.5
作者：
Audesse, Amanda J.;Dhakal, Shleshma;Webb, Ashley E.
通讯作者：
Webb, Ashley E.
DOI：
10.1126/science.1257998
发表时间：
2014-10-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen BC;Legant WR;Wang K;Shao L;Milkie DE;Davidson MW;Janetopoulos C;Wu XS;Hammer JA 3rd;Liu Z;English BP;Mimori-Kiyosue Y;Romero DP;Ritter AT;Lippincott-Schwartz J;Fritz-Laylin L;Mullins RD;Mitchell DM;Bembenek JN;Reymann AC;Böhme R;Grill SW;Wang JT;Seydoux G;Tulu US;Kiehart DP;Betzig E
通讯作者：
Betzig E