Nickel-Catalyzed Amination of Aryl Pivalates by the Cleavage of Aryl C-O Bonds
Nickel-Catalyzed Amination of Aryl Pivalates by the Cleavage of Aryl C-O Bonds
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DOI：
10.1002/anie.200907287
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Chatani, Naoto
中科院分区：
文献类型：
--
作者：
Shimasaki, Toshiaki;Tobisu, Mamoru;Chatani, Naoto
催化胺化反应：标题反应证明了芳基羧酸盐在催化胺化反应中用作合适的亲电偶联底物。N-杂环卡宾配体和NaOtBu通过裂解通常不反应的芳基碳氧键(见方案；CoD=环辛二烯)促进芳基腐戊酸酯的胺化。
Catalytic amination: The title reaction demonstrates the use of aryl carboxylates as suitable electrophilic coupling substrates in catalytic amination reactions. N-heterocyclic carbene ligands and NaOtBu promote the amination of aryl pivalates through the cleavage of normally unreactive aryl carbon-oxygen bonds (see scheme; cod= cyclooctadiene).