Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men
Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men
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DOI：
10.1016/j.drugalcdep.2007.11.010
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发表时间：
2008-04-01
影响因子：
4.2
通讯作者：
Detels, Roger
中科院分区：
文献类型：
--
作者：
Chao, Chun;Jacobson, Lisa P.;Detels, Roger
娱乐性药物对人类CD4和CD8 T细胞的影响尚不清楚。我们对参加多中心艾滋病队列研究（MACS）的男男性行为者（MSM）进行了纵向分析，以确定自我报告的大麻，可卡因，poppers和安非他明的使用与HIV未感染和HIV感染的MSM中CD4和CD8 T细胞参数之间的关联。对于HIV感染的MSM，我们使用1996年之前每半年收集的临床和实验室数据，以避免抗逆转录病毒治疗的潜在影响。使用允许随机截距和斜率以及受试者内误差的自回归协方差结构的回归模型。调整的潜在混杂因素包括随访时间、人口统计学、吸烟、饮酒、危险性行为、性传播感染史和抗病毒治疗。我们发现，在未感染或未感染HIV的男性中，使用大麻、可卡因、poppers或安非他明与CD4和CD8 T细胞计数、百分比或变化率之间没有临床意义的关联。尽管一些回归系数达到了统计学显著性，但回归系数的幅度最小。在过去一年中，没有检测到频繁（至少每周一次）或连续使用药物的阈值效应。这些结果表明，使用这些物质不会对HIV未感染或感染的MSM中循环CD4或CD8 T细胞的数量和百分比产生不利影响。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
The effects of recreational drugs on CD4 and CD8 T cells in humans are not well understood. We conducted a longitudinal analysis of men who have sex with men (MSM) enrolled in the Multicenter AIDS Cohort Study (MACS) to define associations between self-reported use of marijuana, cocaine, poppers and amphetamines, and CD4 and CD8 T cell parameters in both HIV-uninfected and HIV-infected MSM. For the HIV-infected MSM, we used clinical and laboratory data collected semiannually before 1996 to avoid potential effects of antiretroviral treatment. A regression model that allowed random intercepts and slopes as well as autoregressive covariance structure for within subject errors was used. Potential confounders adjusted for included length of follow-up, demographics, tobacco smoking, alcohol use, risky sexual behaviors, history of sexually transmitted infections, and antiviral therapy. We found no clinically meaningful associations between use of marijuana, cocaine, poppers, or amphetamines and CD4 and CD8 T cell counts, percentages, or rates of change in either HIV-uninfected or -infected men. The regression coefficients were of minimum magnitude despite some reaching statistical significance. No threshold effect was detected for frequent (at least weekly) or continuous substance use in the previous year. These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM. (c) 2007 Elsevier Ireland Ltd. All rights reserved.