Amniotic membrane covering promotes healing of cornea epithelium and improves visual acuity after debridement for fungal keratitis
Amniotic membrane covering promotes healing of cornea epithelium and improves visual acuity after debridement for fungal keratitis
复制标题
羊膜覆盖促进角膜上皮愈合并提高真菌性角膜炎清创后的视力
DOI：
10.3980/j.issn.2222-3959.2014.05.08
复制
发表时间：
2014-10-18
影响因子：
1.4
通讯作者：
Li, Gui-Gang
中科院分区：
文献类型：
--
作者：
Zeng, Bo;Wang, Ping;Li, Gui-Gang
目的：为探讨羊膜覆盖对真菌性角膜炎清创术后角膜上皮愈合及视力的影响，将20例真菌性角膜炎患者随机分为羊膜覆盖组和对照组，每组10例。AMC组在常规抗真菌药物治疗的基础上行角膜清创术，AMC组用10-0尼龙线将单层羊膜缝合于整个角膜及球结膜表面。裂隙灯显微镜下测量溃疡直径，眼前节光学相干断层扫描仪测量浸润深度。分别于术前及上皮层愈合后3个月检测裸眼视力（UCVA）。结果：两组术前角膜溃疡直径、浸润深度、前房积脓高度、视力比较差异无统计学意义（P>0.05）。AMC组平均愈合时间为6.89 ± 2.98 d，明显短于对照组的10.23 ± 2.78 d（P
AIM: To investigate the effect of amniotic membrane covering (AMC) on the healing of cornea epithelium and visual acuity for fungal keratitis after debridement.METHODS: Twenty fungal keratitis patients were divided into two groups randomly, the AMC group and the control group, ten patients each group. Both debridement of the infected cornea tissue and standard anti -fungus drugs treatments were given to every patients, monolayer amniotic membrane were sutured to the surface of the entire cornea and bulbar conjunctiva with 10-0 nylon suture for patients in the AMC group. The diameter of the ulcer was determined with slit lamp microscope and the depth of the infiltration was determined with anterior segment optical coherence tomography. Uncorrected visual acuity (UCVA) was tested before surgery and three month after healing of the epithelial layer. The healing time of the cornea epithelium, visual acuity (VA) was compared between the two groups using t-test.RESULTS: There was no statistical difference of the diameter of the ulcer, depth of the infiltration, height of the hypopyon and VA between the two groups before surgery (P>0.05). The average healing time of the AMC group was 6.89 +/- 2.98d, which was statistically shorter than that of the control group (10.23 +/- 2.78d) (P