Development of new simple molecular probes of DNA bulged structures.
Development of new simple molecular probes of DNA bulged structures.
复制标题
DOI：
10.1016/j.bmcl.2006.03.006
复制
发表时间：
2006-06
影响因子：
2.7
通讯作者：
Ziwei Xiao;L. Kappen;I. Goldberg
中科院分区：
文献类型：
--
作者：
Ziwei Xiao;L. Kappen;I. Goldberg
NCSi-gb is a neocarzinostatin chromophore (NCS-chrom) metabolite which binds strongly to certain two-base DNA bulges. Compared with previously reported NCSi-gb analogues, a new analogue with a different aminoglycoside position was synthesized, and it showed strong fluorescence and improved binding and sequence selectivity to DNA bulges. The N-dimethylated form of this analogue had a similar binding pattern, and it competitively inhibited bulge-specific cleavage by NCS-chrom.
