Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis
Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis
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DOI：
10.1016/j.jhep.2006.10.009
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发表时间：
2007-03-01
影响因子：
25.7
通讯作者：
Gretch, David R.
中科院分区：
文献类型：
--
作者：
Bonkovsky, Herbert L.;Snow, Kristin K.;Gretch, David R.
背景/目标：虽然聚乙二醇干扰素/利巴韦林治疗的抗病毒和组织学益处已得到充分证实，但对健康相关生活质量（HRQOL）和性健康的影响尚不确定。本研究评估了HRQOL和性健康在HALT-C Trial.Methods：受试者完成SF-36和性健康问卷调查之前和之后24周的聚乙二醇干扰素/利巴韦林治疗（n = 1144）的晚期纤维化或肝硬化患者。373例（33%）受试者在第20周时为HCV RNA阴性，并继续治疗至第48周;第72周时观察到258例。180人达到持续病毒学应答（SVR），78人复发。结果：在基线时，患者的SF-36所有8个领域的评分均低于健康对照组。肝硬化患者的HRQOL评分低于桥接纤维化患者，抑郁评分较高的患者也是如此。SVR患者在七个领域有显着改善，而复发者在一个领域有显着恶化。SVR患者的性评分改善，复发者降低（p = 0.03）。在多变量分析中，HRQOL和性评分的改善与SVR显着相关，但较低的抑郁scores.Conclusions：实现SVR后聚乙二醇干扰素/利巴韦林治疗改善HRQOL和性健康的慢性丙型肝炎患者晚期纤维化或肝硬化。(c)2006年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: Although the antiviral and histological benefits of peginterferon/ribavirin therapy are well established, the effects on health-related quality of life (HRQOL) and sexual health are less certain. This study assessed HRQOL and sexual health in patients with advanced fibrosis or cirrhosis in the HALT-C Trial.Methods: Subjects completed SF-36 and sexual health questionnaires prior to and after 24 weeks of peginterferon/ribavirin therapy (n = 1144). Three hundred and seventy-three (33%) subjects were HCV RNA negative at week 20 and continued therapy through week 48; 258 were seen at week 72. One hundred and eighty achieved sustained virological responses (SVR) and 78 relapsed.Results: At baseline, patients had poorer scores for all eight SF-36 domains compared to healthy controls. Patients with cirrhosis had lower HRQOL scores than those with bridging fibrosis, as did patients with higher depression scores. SVR patients had significant improvements in seven domains, whereas relapsers had significant worsening in one domain. Sexual scores improved in SVR patients and decreased in relapsers (p = 0.03). In multivariate analyses, improvements in HRQOL and sexual scores were significantly associated with SVR but were less striking in patients with lower depression scores.Conclusions: Achievement of SVR after peginterferon/ribavirin therapy improves HRQOL and sexual health in chronic hepatitis C patients with advanced fibrosis or cirrhosis. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.