Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma.
Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma.
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发表时间：
2007-11
影响因子：
2
通讯作者：
T. Fukushima;H. Kataoka
中科院分区：
文献类型：
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作者：
T. Fukushima;H. Kataoka
据报道，胰岛素样生长因子结合蛋白-2（IGFBP-2）是胰岛素样生长因子（IGFs）作用的调节剂，而IGFBP-2对细胞增殖、凋亡和迁移率的IGF非依赖性作用不仅在胚胎状态期间而且在癌症的病理状态中被揭示。与其他类型的癌一样，IGFBP-2的过表达已在多形性胶质母细胞瘤（GBM）中被报道，GBM是以快速生长、广泛侵袭和血管生成为特征的最恶性的脑肿瘤。然而，目前尚不清楚IGFBP-2是如何参与GBM的恶性特征。本文综述了IGFBP-2的IGF依赖性和非依赖性功能，并重点介绍了IGFBP-2在GBM进展中的作用。
Insulin-like growth factor binding protein-2 (IGFBP-2) is reported to be a modulator of the action of insulin-like growth factors (IGFs), whereas IGF-independent effects of IGFBP-2 on cellular proliferation, apoptosis, and mobility have been revealed not only during the embryonic state but also in the pathological state of cancer. As well as other types of carcinomas, overexpression of IGFBP-2 has been reported in glioblastoma multiforme (GBM), the most malignant brain tumor characterized by rapid growth, extensive invasiveness, and angiogenesis. However, it remains unclear how IGFBP-2 is involved in the malignant features of GBM. This review outlines the IGF-dependent and -independent functions of IGFBP-2 and focuses on the roles of IGFBP-2 in the progression of GBM.