Depression symptomatology correlates with event-related potentials in Parkinson's disease: An affective priming study
Depression symptomatology correlates with event-related potentials in Parkinson's disease: An affective priming study
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DOI：
10.1016/j.jad.2018.11.094
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发表时间：
2019-02-15
影响因子：
6.6
通讯作者：
Copland, David A.
中科院分区：
文献类型：
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作者：
Dissanayaka, Nadeeka N. W.;Au, Tiffany R.;Copland, David A.
背景：抑郁症是帕金森病 (PD) 的主要非运动症状，但人们常常对其认识不足且治疗不足。为了提高对帕金森病抑郁症的识别，必须检查客观的大脑相关标志物。本研究通过使用脑电图（EEG）来评估PD中情绪化词语的处理来解决这一差距。方法：50名未接受抑郁或焦虑药物治疗的非痴呆PD患者完成情感启动任务，同时记录脑电图。负价或中性价的主要词和目标词对以 250 毫秒的刺激开始异步呈现。参与者被要求通过按下按钮来评估目标词的效价。使用既定的评定量表来测量抑郁症。我们进行了协方差和相关分析的重复测量分析，以检查事件相关电位 (ERP) 是否随抑郁评分的变化而变化。结果：ERP 的关键发现显示，抑郁评分较高的患者中，一致和不一致的中性目标之间的顶叶中线 P300、N400 和晚期正电位 (LPP) 差异波的反应减少。 局限性：由于对患有和不患有临床抑郁症的参与者分类不充分，ERP 的比较受到限制。大多数抑郁评分较高的 PD 患者被排除在分析之外，因为他们正在接受可能干扰 ERP 敏感性的抗抑郁药物和/或抗焦虑药物。 结论：本研究表明，Pz-P300、N400 和 LPP 是与 PD 情绪功能障碍相关的 ERP 标志物。因此，这些发现推进了有关帕金森病常见神经精神缺陷的神经生理学标志物的当前知识。
Background: Depression is a predominant non-motor symptom of Parkinson's disease (PD), which is often under recognised and undertreated. To improve identification of depression in PD it is imperative to examine objective brain-related markers. The present study addresses this gap by using electroencephalography (EEG) to evaluate the processing of emotionally valanced words in PD.Methods: Fifty non-demented PD patients, unmedicated for depression or anxiety, completed an affective priming task while EEG was simultaneously recorded. Prime and target word pairs of negative or neutral valence were presented at a short 250 ms stimulus onset asynchrony. Participants were asked to evaluate the valence of the target word by button press. Depression was measured using an established rating scale. Repeated measures analysis of covariance and correlational analyses were performed to examine whether event-related potentials (ERP) varied as a function of depression scores.Results: Key ERP findings reveal reduced responses in parietal midline P300, N400 and Late Positive Potential (LPP) difference waves between congruent and incongruent neutral targets in patients with higher depression scores.Limitations: Comparisons of ERPs were limited by insufficient classification of participants with and without clinical depression. A majority of PD patients who had high depression scores were excluded from the analysis as they were receiving antidepressant and/or anxiolytic medications which could interfere with ERP sensitivity.Conclusions: The present study suggests that the Pz-P300, N400 and LPP are ERP markers relates to emotional dysfunction in PD. These findings thus advance current knowledge regarding the neurophysiological markers of a common neuropsychiatric deficit in PD.