Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases.
Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases.
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基因靶向揭示了磷酸肌醇 3-激酶的生理作用和复杂调节。
DOI：
10.1016/s0003-9861(03)00177-2
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发表时间：
2003
影响因子：
3.9
通讯作者：
K. Okkenhaug
中科院分区：
文献类型：
--
作者：
L. Foukas;K. Okkenhaug
磷酸肌醇 3-激酶 (PI3K) 由八种不同的酶组成，根据其结构和功能可分为三类。 The class I PI3Ks are heterodimeric enzymes that are regulated by recruitment to plasma membrane following receptor activation and which control numerous cellular functions, including growth, differentiation, migration, survival, and metabolism. New light has been shed on the biological role of individual members of the class I PI3Ks and their regulatory subunits through gene-targeting experiments. In addition, these experiments have brought the complexity of how PI3K activation is regulated into focus.
Phosphoinositide 3-kinases (PI3Ks) are represented by a family of eight distinct enzymes that can be divided into three classes based on their structure and function. The class I PI3Ks are heterodimeric enzymes that are regulated by recruitment to plasma membrane following receptor activation and which control numerous cellular functions, including growth, differentiation, migration, survival, and metabolism. New light has been shed on the biological role of individual members of the class I PI3Ks and their regulatory subunits through gene-targeting experiments. In addition, these experiments have brought the complexity of how PI3K activation is regulated into focus.
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影响因子：
15.9
作者：
Mauvais-Jarvis, F;Ueki, K;Kahn, CR
通讯作者：
Kahn, CR
DOI：
10.1073/pnas.96.4.1563
发表时间：
1999-02-16
影响因子：
11.1
作者：
Podsypanina, K;Ellenson, LH;Parsons, R
通讯作者：
Parsons, R
影响因子：
56.9
作者：
Fruman, DA;Snapper, SB;Cantley, LC
通讯作者：
Cantley, LC
影响因子：
50.3
作者：
Chan, TO;Rodeck, U;Tsichlis, PN
通讯作者：
Tsichlis, PN
PTEN 的条件性缺失会导致乳腺发育早熟和肿瘤形成。
DOI：
10.1242/dev.129.17.4159
发表时间：
2002
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Li,Gang;Robinson,GertraudW;Lesche,Ralf;Martinez-Diaz,Hilda;Jiang,Zhaorong;Rozengurt,Nora;Wagner,Kay-Uwe;Wu,De-Chang;Lane,TimothyF;Liu,Xin;Hennighausen,Lothar;Wu,Hong
通讯作者：
Wu,Hong