Model of local temperature changes in brain upon functional activation
Model of local temperature changes in brain upon functional activation
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DOI：
10.1152/japplphysiol.00626.2004
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发表时间：
2004-12-01
影响因子：
3.3
通讯作者：
Turner, R
中科院分区：
文献类型：
--
作者：
Collins, CM;Smith, MB;Turner, R
在功能激活过程中，脑温度变化的实验结果显示出很大的变化。因此，有必要为这种变化建立一个严谨的数值模型。在这里，使用生物热方程的三维人体头部温度模型，包括代谢、灌注和热传导的影响，用于检查由于大脑功能激活而导致的潜在温度变化。我们发现，根据大脑的位置和相应的基线温度相对于血液温度的不同，温度可能随着激活而升高或降低，并伴随灌注和代谢率的增加。灌注的变化通常比代谢的变化对温度的影响更大，因此预测活跃的大脑会从初始温度接近血液温度。在合理的生理参数下，所有计算出的温度变化都是有幅度的
Experimental results for changes in brain temperature during functional activation show large variations. It is, therefore, desirable to develop a careful numerical model for such changes. Here, a three-dimensional model of temperature in the human head using the bioheat equation, which includes effects of metabolism, perfusion, and thermal conduction, is employed to examine potential temperature changes due to functional activation in brain. It is found that, depending on location in brain and corresponding baseline temperature relative to blood temperature, temperature may increase or decrease on activation and concomitant increases in perfusion and rate of metabolism. Changes in perfusion are generally seen to have a greater effect on temperature than are changes in metabolism, and hence active brain is predicted to approach blood temperature from its initial temperature. All calculated changes in temperature for reasonable physiological parameters have magnitudes