Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial
Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial
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DOI：
10.1111/j.1600-0501.2010.01981.x
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发表时间：
2011-03-01
影响因子：
4.3
通讯作者：
Raghoebar, G. M.
中科院分区：
文献类型：
--
作者：
Rickert, D.;Sauerbier, S.;Raghoebar, G. M.
目的评价上颌窦底提升术中混合自体骨或自体干细胞的牛骨矿物质（BioOss（R））在骨形成方面是否存在差异。主要终点是新骨的百分比三个月后elevation procedure.Material and methodsIn一个随机的，对照的裂口设计，在12个连续的患者（年龄60.8 +/- 5.9岁，范围48-69岁）需要重建他们的萎缩上颌骨，双边窦底隆升程序进行。随机地，在一侧使用牛骨矿物质（BioOss（R））进行增强手术，所述牛骨矿物质（BioOss（R））接种有从后髂嵴收获的单核干细胞（试验组），而BioOss（R）与自体骨（从磨牙后区域收获）混合应用于对侧（对照组）。在窦底提升后14.8 +/- 0.7周，在随后放置骨内植入物的位置从重建区域进行活检。组织形态计量学分析的活检标本。结果显着更多的骨形成观察到在试验组（17.7 +/- 7.3%）相比，对照组（12.0% +/- 6.6; P=0.026）。在试验组和对照组中，所有植入物均能以初期稳定性放置。在一名患者中，并非所有活检都含有BioOss（R）。该患者被排除在分析之外。结论间充质干细胞接种在BioOss（R）颗粒上可以诱导形成足够体积的新骨，从而能够在与单独应用自体骨或自体骨和BioOss（R）的混合物相当的时间范围内可靠地放置种植体。引用本文：里克特D，Sauerbier S，Nagursky H，Menne D，Vissink A，Raghoebar GM.牛骨矿物质联合自体骨或自体干细胞提升上颌窦底：一项前瞻性随机临床试验。Res. 22，2011; 251-258.doi：10.1111/j.1600-0501.2010.01981.x.
AimTo assess whether differences occur in bone formation after maxillary sinus floor elevation surgery with bovine bone mineral (BioOss (R)) mixed with autogenous bone or autogenous stem cells. The primary endpoint was the percentage of new bone three months after the elevation procedure.Material and methodsIn a randomized, controlled split-mouth design, in 12 consecutive patients (age 60.8 +/- 5.9 years, range 48-69 years) needing reconstruction of their atrophic maxilla, a bilateral sinus floor augmentation procedure was performed. Randomly, on one side the augmentation procedure was performed with bovine bone mineral (BioOss (R)) seeded with mononuclear stem cells harvested from the posterior iliac crest (test group) while BioOss (R) mixed with autogenous bone (harvested from the retromolar area) was applied on the contra-lateral side (control group). On 14.8 +/- 0.7 weeks after the sinus floor elevation, biopsies from the reconstructed areas were taken at the spots where subsequently the endosseous implants were placed. The biopsies were histomorphometrically analyzed.ResultsSignificantly more bone formation was observed in the test group (17.7 +/- 7.3%) when compared with the control group (12.0% +/- 6.6; P=0.026). In both the test and control group, all implants could be placed with primary stability. In one patient, not all biopsies contained BioOss (R). This patient was excluded from analysis.ConclusionMesenchymal stem cells seeded on BioOss (R) particles can induce the formation of a sufficient volume of new bone to enable the reliable placement of implants within a time frame comparable with that of applying either solely autogenous bone or a mixture of autogenous bone and BioOss (R). This technique could be an alternative to using autografts.To cite this article: Rickert D, Sauerbier S, Nagursky H, Menne D, Vissink A, Raghoebar GM. Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial.Clin. Oral Impl. Res. 22, 2011; 251-258.doi: 10.1111/j.1600-0501.2010.01981.x.