Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder.

Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder.
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氢化可的松会损害创伤后应激障碍中海马依赖性的微量眨眼调节。

DOI：
10.1038/sj.npp.1300843
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发表时间：
2006
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
通讯作者：
Grillon,Christian
Grillon,Christian
中科院分区：
--
文献类型：
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作者：
Vythilingam,Meena;Lawley,Megan;Collin,Carlos;Bonne,Omer;Agarwal,Rajni;Hadd,Kayleen;Charney,DennisS;Grillon,Christian

文献摘要

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微量眨眼条件反射是一项依赖于海马的联想学习任务，有助于评估创伤后应激障碍 (PTSD) 中的海马功能。由于临床前研究已经证明微量眨眼条件反射可以通过糖皮质激素进行药理学操纵，因此这项任务可能有助于揭示 PTSD 中糖皮质激素的敏感性。这项研究评估了 PTSD 患者和健康对照者的基线和氢化可的松介导的微量眨眼调节的变化。总共 12 名 PTSD 患者和 12 名年龄和性别匹配的健康对照者在静脉注射 30 毫克氢化可的松后 6 小时参加了微量眨眼测试。 PTSD 患者和健康对照者的自发眨眼率相似。在安慰剂条件下，PTSD 受试者和健康对照者的平均条件反应没有显着差异。给予氢化可的松后，只有 PTSD 患者表现出条件反应显着降低，而健康受试者则没有表现出任何变化。 PTSD 患者在介导微量眨眼条件反射的大脑局部区域糖皮质激素敏感性增加。
Trace eyeblink conditioning is a hippocampal-dependent associative learning task that could help evaluate hippocampal function in Post-traumatic stress disorder (PTSD). Since preclinical research has demonstrated that trace eyeblink conditioning can be pharmacologically manipulated by glucocorticoids, this task may shed light on glucocorticoid sensitivity in PTSD. This study assessed baseline and hydrocortisone-mediated changes in trace eyeblink conditioning in patients with PTSD and in healthy controls. A total of 12 patients with PTSD and 12 age-and sex-matched healthy controls participated in a trace eyeblink test 6 h following intravenous administration of 30 mg of hydrocortisone. Spontaneous blink rates were similar between PTSD patients and healthy controls. There was no significant difference in the mean conditioned response between PTSD subjects and healthy controls under placebo conditions. Following hydrocortisone administration, only the PTSD patients demonstrated a significant reduction in conditioned response in contrast to healthy subjects who did not demonstrate any change. Patients with PTSD had increased glucocorticoid sensitivity in the focal brain regions mediating trace eyeblink conditioning.