The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons
The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons
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DOI：
10.1523/jneurosci.0604-09.2009
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发表时间：
2009-07-22
影响因子：
5.3
通讯作者：
Marin, Oscar
中科院分区：
文献类型：
--
作者：
Gelman, Diego M.;Martini, Francisco J.;Marin, Oscar
GABA能中间神经元在大脑皮层的功能中起着重要作用。通过主要的抑制机制，中间神经元控制超兴奋性，并同步和塑造各种脑功能背后的皮层活动的时空动力学。过去10年的研究表明，在大多数哺乳动物中，中间神经元在发育过程中起源于皮质下端脑（苍白球下），并通过切线迁移到达大脑皮层。到目前为止，已证明中间神经元只来自两个下苍白球区域，内侧神经节隆起和尾侧神经节隆起。在这里，我们表明，另一个苍白球下结构，视前区，是一个新的来源皮质GABA能中间神经元在小鼠。在子宫内标记和遗传谱系追踪实验表明，在这个区域出生的神经元迁移到新皮层和海马，在那里他们分化成一个独特的群体的GABA能中间神经元相对统一的神经化学，形态学和电生理特性。
GABA-containing (GABAergic) interneurons play an important role in the function of the cerebral cortex. Through mostly inhibitory mechanisms, interneurons control hyperexcitability and synchronize and shape the spatiotemporal dynamics of cortical activity underlying various brain functions. Studies over the past 10 years have demonstrated that, in most mammals, interneurons originate during development from the subcortical telencephalon-the subpallium-and reach the cerebral cortex through tangential migration. Until now, interneurons have been demonstrated to derive exclusively from two subpallial regions, the medial ganglionic eminence and the caudal ganglionic eminence. Here, we show that another subpallial structure, the preoptic area, is a novel source of cortical GABAergic interneurons in the mouse. In utero labeling and genetic lineage-tracing experiments demonstrate that neurons born in this region migrate to the neocortex and hippocampus, where they differentiate into a distinct population of GABAergic interneurons with relatively uniform neurochemical, morphological, and electrophysiological properties.