[Odontoclasts and calcitonin].
[Odontoclasts and calcitonin].
复制标题
DOI：
--
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
K. Okabe;F. Okamoto;H. Kajiya
中科院分区：
文献类型：
--
作者：
K. Okabe;F. Okamoto;H. Kajiya
尽管人们认为介导乳牙根部吸收的破牙细胞具有破骨细胞的共同特性，但这些调节机制与破骨细胞的骨吸收不同。降钙素受体是一种重要的破骨细胞标志物，降钙素是一种有效的骨细胞骨吸收抑制激素。然而，降钙素受体在人类破牙细胞中的存在和功能仍然存在争议。我们总结了破牙细胞的生理特性和分化机制，以及降钙素对牙根吸收的影响，包括我们最近使用人破牙细胞和乳牙牙根新鲜分离的牙周膜细胞的结果。
Although it is believed that odontoclasts, which mediated root resorption of deciduous teeth, possess common properties to osteoclasts, these regulatory mechanisms differ from osteoclastic bone resorption. It is well established that calcitonin receptor is an important osteoclast marker and that calcitonin is a potent inhibitory hormone of osteoclastic bone resorption. However, the presence and function of calcitonin receptors in human odontoclasts are still controversial. We summarize the physiological properties and differentiation mechanisms of odontoclasts, and the effects of calcitonin on root resorption, including our recent results using human odontoclasts and periodontal ligament cells freshly isolated from deciduous tooth roots.