Overexpression of MDM2 in acute childhood lymphoblastic leukemia
Overexpression of MDM2 in acute childhood lymphoblastic leukemia
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DOI：
10.3109/08880019809018313
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发表时间：
1998-11-01
影响因子：
1.7
通讯作者：
Gustafsson, B
中科院分区：
文献类型：
--
作者：
Gustafsson, B;Stal, O;Gustafsson, B
TP53基因突变是多种肿瘤中最常见的分子改变之一，但它在儿童和成人血液恶性肿瘤中很少发生。蛋白质积累通常是由p53蛋白失活的突变引起的。p53蛋白功能性失活的其他原因包括通过MDM2等蛋白来稳定p53， MDM2是一种能够与p53形成特定复合物的癌蛋白。本研究采用免疫组化方法对23例1-13岁急性淋巴细胞白血病患者骨髓标本中MDM2和p53蛋白的表达进行了研究。p53蛋白过表达仅1例，而MDM2过表达在Jive患者样本中检测到。5例MDM2过表达患者均属于诊断时预后不良组，其中3例在诊断后6个月内复发或死亡。
Mutation of the TP53 gene is one of the most common molecular alterations in a variety of tumors, but it occurs infrequently in childhood and adult hematological malignancies. Protein accumulation often results from mutations that lead to inactivation of the p53 protein. Other causes of functional inactivation of the p53 protein include stabilization of p53 via proteins such as MDM2, an oncoprotein capable of forming specific complexes with p53. In the present study, protein expressions of MDM2 and p53 were investigated by immunohistochemistry from bone marrow samples in 23 patients with acute lymphoblastic leukemia aged 1-13 years at diagnosis. p53 protein overexpression was detected in only one case, while overexpression of MDM2 was detected in samples from Jive patients. All five patients overexpressing MDM2 belonged to a group with unfavorable prognostic signs at diagnosis and three of them relapsed or died within 6 months after diagnosis.