Heme Burden and Ensuing Mechanisms That Protect the Kidney: Insights from Bench and Bedside.
Heme Burden and Ensuing Mechanisms That Protect the Kidney: Insights from Bench and Bedside.
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血红素负担和随之而来的保护肾脏的机制：来自临床和临床的见解。
DOI：
10.3390/ijms22158174
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发表时间：
2021-07-30
影响因子：
5.6
通讯作者：
Zarjou A
中科院分区：
文献类型：
--
作者：
Balla J;Zarjou A
以铁为核心的四吡咯血红素环是一个主要的修复基团，由许多蛋白质组成，参与广泛的细胞功能和新陈代谢。一旦释放，由于其促氧化特性，足够数量的游离血红素可能会对肾脏和其他器官造成损害。血红素加氧酶-1(HO-1)通过促进血红素降解成等摩尔量的一氧化碳、铁和胆绿素，从而迅速关注这种损伤潜力。在各种疾病的动物模型中，HO-1的诱导是对组织损伤的有益反应，包括那些影响肾脏的疾病。这些保护属性主要是由于：(I)血红素的迅速降解导致抑制游离血红素的潜在危险影响，以及(Ii)副产物的产生以及铁蛋白的诱导在许多病理条件下被证明是有益的。这篇综述将集中于描述一些疾病的临床方面，其统一的最终结果是增加血红素负担，并将讨论随后保护肾脏的分子机制。
With iron at its core, the tetrapyrrole heme ring is a cardinal prosthetic group made up of many proteins that participate in a wide array of cellular functions and metabolism. Once released, due to its pro-oxidant properties, free heme in sufficient amounts can result in injurious effects to the kidney and other organs. Heme oxygenase-1 (HO-1) has evolved to promptly attend to such injurious potential by facilitating degradation of heme into equimolar amounts of carbon monoxide, iron, and biliverdin. HO-1 induction is a beneficial response to tissue injury in diverse animal models of diseases, including those that affect the kidney. These protective attributes are mainly due to: (i) prompt degradation of heme leading to restraining potential hazardous effects of free heme, and (ii) generation of byproducts that along with induction of ferritin have proven beneficial in a number of pathological conditions. This review will focus on describing clinical aspects of some of the conditions with the unifying end-result of increased heme burden and will discuss the molecular mechanisms that ensue to protect the kidneys.
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影响因子：
3
作者：
Aubouy A;Olagnier D;Bertin G;Ezinmegnon S;Majorel C;Mimar S;Massougbodji A;Deloron P;Pipy B;Coste A
通讯作者：
Coste A
影响因子：
13.2
作者：
Barber BE;Grigg MJ;Piera KA;William T;Cooper DJ;Plewes K;Dondorp AM;Yeo TW;Anstey NM
通讯作者：
Anstey NM
影响因子：
15.9
作者：
Belcher, JD;Mahaseth, H;Vercellotti, GM
通讯作者：
Vercellotti, GM
DOI：
10.2215/cjn.00590120
发表时间：
2020-07-01
影响因子：
9.8
作者：
Amoura, Ariane;Moktefi, Anissa;Audard, Vincent
通讯作者：
Audard, Vincent
影响因子：
6.1
作者：
Balla, Jozsef;Vercellotti, Gregory A.;Balla, Gyorgy
通讯作者：
Balla, Gyorgy