Antidepressant-like properties of zinc in rodent forced swim test
Antidepressant-like properties of zinc in rodent forced swim test
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DOI：
10.1016/s0361-9230(01)00473-7
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发表时间：
2001-05-15
影响因子：
3.8
通讯作者：
Nowak, G
中科院分区：
文献类型：
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作者：
Kroczka, B;Branski, P;Nowak, G
采用小鼠和大鼠强迫游泳实验研究了N-甲基-D-天冬氨酸谷氨酸受体抑制剂锌的作用。锌（硫酸锌）在30 mg/kg的剂量和丙咪嗪（30 mg/kg），减少不动的时间在两个物种的强迫游泳试验。此外，在本试验中，锌和丙咪嗪以其无效剂量（分别为1和5 mg/kg）联合给药在大鼠中诱导了统计学显著性效应。强迫游泳试验中的活性剂量降低（小鼠）或不影响（大鼠）自发活动。所获得的结果表明，锌诱导抗抑郁样作用，并增强丙咪嗪在强迫游泳试验中的作用，这表明锌在人类中具有潜在的抗抑郁活性。(C)2001 Elsevier Science Inc.
The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test. Zinc (ZnSO4) in a dose of 30 mg/kg and imipramine (30 mg/kg), reduced the immobility time in the forced swim test in both species. Moreover, combined treatment in this test with zinc and imipramine at their ineffective doses (1 and 5 mg/kg, respectively) induced a statistically significant effect in rats. The doses active in the forced swim test reduced (in mice) or did not affect (in rats) locomotor activity. The results obtained indicate that zinc induces an antidepressant-like effect and enhances the effect of imipramine in the forced swim test, suggesting a potential antidepressant activity of zinc in humans. (C) 2001 Elsevier Science Inc.