SITE-SPECIFIC INCORPORATION OF NONNATURAL RESIDUES INTO PEPTIDES - EFFECT OF RESIDUE STRUCTURE ON SUPPRESSION AND TRANSLATION EFFICIENCIES
SITE-SPECIFIC INCORPORATION OF NONNATURAL RESIDUES INTO PEPTIDES - EFFECT OF RESIDUE STRUCTURE ON SUPPRESSION AND TRANSLATION EFFICIENCIES
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DOI：
10.1016/s0040-4020(01)81776-2
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发表时间：
1991-04-08
期刊：
影响因子：
2.1
通讯作者：
CHAMBERLIN, AR
中科院分区：
文献类型：
--
作者：
BAIN, JD;WACKER, DA;CHAMBERLIN, AR
系统调查的非天然残基生物合成纳入多肽的结构要求。 一系列的12个半合成的酰化抑制tRNA的相对翻译效率范围从0到91%，这取决于残基的结构纳入。
A systematic survey of the structural requirements for biosynthetic incorporation of non-natural residues into a polypeptide is presented. Relative translation efficiencies for a series of 12 semi-synthetic acylated suppressor tRNAs ranged from 0 to 91% depending on the structure of the residue incorporated.