The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene
The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene
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人免疫球蛋白C-gamma-1基因的核苷酸序列
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
L. Hood
中科院分区：
文献类型：
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作者：
J. Ellison;B. Berson;L. Hood
我们报道了编码人免疫球蛋白γ-1重链(C-γ-1)恒定区基因的核苷酸序列。将该序列与Cγ2和Cγ4基因的序列进行比较，发现这3个人类Cγ基因在编码区和非编码区都有相当大的同源性。核苷酸序列的差异表明，这些基因在大约600-800万年前彼此背道而驰。对铰链外显子的研究表明，在碱基替换和缺失插入事件方面，这些编码区的进化速度比Cγ基因的任何其他区域都要快。在与铰链接壤的CH结构域的区域中也观察到编码序列多样性。
We report the nucleotide sequence of a gene encoding the constant region of a human immnnoglobulin γ1 heavy chain (Cγ1). A comparison of this sequence with those of the Cγ2 and Cγ4 genes reveals that these three human Cγ genes share considerable homology in both coding and noncoding regions. The nucleotide sequence differences indicate that these genes diverged from one another approximately 6–8 million years ago. An examination of hinge exons shows that these coding regions have evolved more rapidly than any other areas of the Cγ genes in terms of both base substitution and deletion–insertion events. Coding sequence diversity also is observed in areas of CH domains which border the hinge.