The Glu27 genotypes of the Beta2-adrenergic receptor are predictors for severe coronary artery disease - Research article
The Glu27 genotypes of the Beta2-adrenergic receptor are predictors for severe coronary artery disease - Research article
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DOI：
10.1186/1471-2350-7-31
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发表时间：
2006-03-30
影响因子：
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通讯作者：
Dzimiri, Nduna
中科院分区：
文献类型：
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作者：
Abu-Amero, Khaled K.;Al-Boudari, Olayan M.;Dzimiri, Nduna
背景资料：β 2-肾上腺素受体（β 2-AR）Gln 27 Glu多态性在心血管疾病中的作用尚不清楚。79 C > G（p.Gln27Glu）多态性与沙特阿拉伯人冠状动脉疾病（CAD）及其相关危险因素结果：普通人群（BD）895例中，野生型C/C纯合型占68.5%，杂合型C/G占28.3%，突变型G/G纯合型占3.2%。在冠心病组（n = 773）中，50.6%为野生型纯合子C/C，43.6%为杂合子C/G，5.8%为突变型纯合子G/G，而在对照组（n = 528）中，71.8%为C/C，24.4%为C/G，3.8%为G/G基因型。这些结果表明，C/G（p = 0.001）和C/G（p = 0.001）均为最大值。
Background: The role of the Beta2-adrenoceptor (beta2-AR) Gln27Glu polymorphism in the manifestation of cardiovascular diseases is still unclear.Methods: In the present study, we evaluated the potential relevance of the c. 79 C > G (p. Gln27Glu) polymorphism of this receptor gene for coronary artery disease (CAD) and its associated risk factors in Saudi Arabs. Genotyping was performed by PCR using the confronting two-pair primer (PCR-CTPP) method.Results: In the general population group (BD) (n = 895), 68.5% were homozygous wild-type C/C, 28.3% were heterozygous C/G and 3.2% were homozygous mutant G/G. Among the CAD patients (n = 773), 50.6% were homozygous wild-type C/C, 43.6% were heterozygous C/G and 5.8% were homozygous mutant G/G, while in the angiographed control group (CON) (n = 528), 71.8% were C/C, 24.4% C/G and 3.8% G/G genotypes. These results indicate that both the C/G ( p =