Placental Histomorphometry in Gestational Diabetes Mellitus The Relationship Between Subsequent Type 2 Diabetes Mellitus and Race/Ethnicity
Placental Histomorphometry in Gestational Diabetes Mellitus The Relationship Between Subsequent Type 2 Diabetes Mellitus and Race/Ethnicity
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DOI：
10.1309/ajcpx81aunfpotll
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发表时间：
2014-04-01
影响因子：
3.5
通讯作者：
Roberts, Drucilla J.
中科院分区：
文献类型：
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作者：
Bentley-Lewis, Rhonda;Dawson, Deanna L.;Roberts, Drucilla J.
目的：我们检查了妊娠糖尿病 (GDM) 中与种族/民族和随后的 2 型糖尿病 (T2DM) 相关的胎盘组织形态计量学因素。方法：我们从单胎、足月活产中鉴定了 124 个胎盘，这些婴儿的母亲具有临床定义的 GDM 和自我报告的种族/民族。从医疗记录中提取临床和胎盘诊断。结果：对 48 名白人和 76 名非白人女性进行了 4.1 年的随访（中位数，范围 0.0-8.9 年）。白人女性患 T2DM 的几率较低（12.5% vs 35.5%；P = .005），但收缩压较高（平均值 +/- SD，116 +/- 13 vs 109 +/- 11 mm Hg；P < .001）和舒张压（71 +/- 9 vs 68 +/- 7 mm Hg；P = .02）血压较高，吸烟较多（35.4% vs 10.5%； .004），并且比非白人女性有更多的胆管病（52.1% vs 30.3%；P = .02）。结论：虽然更多的非白人女性患上 T2DM，但更多的白人女性患有胆管病，这可能是由于其中吸烟者比例较高所致。需要进一步研究来阐明胆管病、随后的母亲 T2DM 和种族之间的关系。
Objectives: We examined placental histomorphometry in gestational diabetes mellitus (GDM) for factors associated with race/ethnicity and subsequent type 2 diabetes mellitus (T2DM).Methods: We identified 124 placentas from singleton, fullterm live births whose mothers had clinically defined GDM and self-reported race/ethnicity. Clinical and placental diagnoses were abstracted from medical records.Results: Forty-eight white and 76 nonwhite women were followed for 4.1 years (median, range 0.0-8.9 years). White women developed less T2DM (12.5% vs 35.5%; P = .005) but had higher systolic (mean +/- SD, 116 +/- 13 vs 109 +/- 11 mm Hg; P < .001) and diastolic (71 +/- 9 vs 68 +/- 7 mm Hg; P = .02) blood pressure, more smoking (35.4% vs 10.5%; P = .004), and more chorangiosis (52.1% vs 30.3%; P = .02) than nonwhite women.Conclusions: Although more nonwhite women developed T2DM, more white women had chorangiosis, possibly secondary to the higher percentage of smokers among them. Further study is necessary to elucidate the relationship among chorangiosis, subsequent maternal T2DM, and race.