Synchronized activity in prefrontal cortex during anticipation of visuomotor processing
Synchronized activity in prefrontal cortex during anticipation of visuomotor processing
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DOI：
10.1097/00001756-200211150-00004
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发表时间：
2002-11-15
期刊：
影响因子：
1.7
通讯作者：
Nakamura, R
中科院分区：
文献类型：
--
作者：
Liang, HL;Bressler, SL;Nakamura, R
人们普遍认为，尽管尚未得到充分证实，前额叶皮层对感觉处理进行自上而下的控制。这种控制的一方面被认为是促进预期这种处理的感觉通路。为了研究前额叶皮层在预期自上而下控制中的可能参与，我们研究了猕猴等待视觉刺激呈现时记录的前额叶活动与随后的感觉和运动事件之间的统计关系。同时记录左大脑半球前额叶、运动、枕叶和颞叶皮质部位的局部场电位。频谱功率和相干性分析表明，在刺激预期期间，五个前额叶部位中的三个参与了在 P 频率范围内同步的相干振荡网络。刺激前网络功率和一致性与视觉皮层区域早期视觉诱发电位成分的幅度和潜伏期以及响应时间高度相关。结果表明，前额叶皮层中的同步振荡网络参与了自上而下的预期机制，促进了视觉皮层随后的感觉处理。他们进一步暗示，更强的自上而下控制会导致更大更快的感官反应，以及随后更快的运动反应。
It is commonly presumed, though not well established, that the prefrontal cortex exerts top-down control of sensory processing. One aspect of this control is thought to be a facilitation of sensory pathways in anticipation of such processing. To investigate the possible involvement of prefrontal cortex in anticipatory top-down control, we studied the statistical relations between prefrontal activity, recorded while a macaque monkey waited for presentation of a visual stimulus, and subsequent sensory and motor events. Local field potentials were simultaneously recorded from prefrontal, motor, occipital and temporal cortical sites in the left cerebral hemisphere. Spectral power and coherence analysis revealed that during stimulus anticipation three of five prefrontal sites participated in a coherent oscillatory network synchronized in the P-frequency range. Pre-stimulus network power and coherence were highly correlated with the amplitude and latency of early visual evoked potential components in visual cortical areas, and with response time. The results suggest that synchronized oscillatory networks in prefrontal cortex are involved in top-down anticipatory mechanisms that facilitate subsequent sensory processing in visual cortex. They further imply that stronger top-down control leads to larger and faster sensory responses, and a subsequently faster motor response.