Regional cerebral blood flow estimated by 133-xenon inhalation.
Regional cerebral blood flow estimated by 133-xenon inhalation.
复制标题
通过吸入 133 氙来估算局部脑血流量。
作者：
W. Obrist;H. Thompson;H. Wang;W. Wilkinson
描述了一种方法，用于从122个XE清除曲线的前10分钟估计大脑的快速（灰质）隔室的清除率和血流分数，随后吸入1分钟。使用计算机模拟数据检测所用双房室模型的充分性，并评价存在随机噪声时参数的稳定性。这种方法和以前报道的三房室分析之间进行了比较。对48例年轻对照者和20例老年痴呆患者进行了局部脑血流数据采集。半球，区域和重测的变化，以及组间的差异进行了测定。
A method is described for estimating the clearance rate and fractional blood flow of the fast (gray matter) compartment of the brain from the first ten minutes of 122 XE clearance curves, following a one-minute inhalation. Computer-simulated data were used to test the adequacy of the two-compartmental model employed, and to evaluate the stability of the parameters in the presence of random noise. A comparison was made between this approach and the previously reported three-compartmental analysis. Regional cerbral blood flow data were obtained on 48 young control subjects and 20 elderly demented patients. Hemispheral, regional, and test-retest variations were determined, as well as differences between the groups.