Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.
Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.
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发表时间：
1985-09
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通讯作者：
R. Custer;G. Bosma;M. Bosma
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作者：
R. Custer;G. Bosma;M. Bosma
严重联合免疫缺陷（SCID）小鼠的组织学结果非常一致，包括淋巴细胞减少症、无皮质的胸腺髓质退化、相对空的脾滤泡和淋巴结以及未发育的支气管和胃肠道淋巴细胞灶。免疫激活细胞分选仪研究显示，胸腺和脾脏中有少量T细胞（显然无功能）;有趣的是，这些细胞似乎高度倾向于瘤形成，因为在269只小鼠中的41只中观察到胸腺T细胞淋巴瘤。未鉴别出前B或B细胞。髓系细胞表现正常。在静脉注射组织相容性骨髓细胞后，实现了淋巴组织重建。
Histologic findings in mice with severe combined immunodeficiency (SCID) were remarkably uniform, consisting of lymphopenia, a rudimentary thymic medulla without cortex, relatively empty splenic follicles and lymph nodes, and undeveloped bronchial and gastrointestinal lymphocytic foci. Fluorescence-activated cell sorter studies revealed a few T cells (apparently nonfunctional) in thymus and spleen; interestingly, these cells seemed highly disposed to neoplasia, because thymic T-cell lymphomas were observed in 41 of 269 mice. No pre-B or B cells could be identified. Cells of the myeloid lineage appeared normal. Reconstitution of lymphoid tissues was achieved after intravenous injection of histocompatible bone marrow cells.