Origin and development of the avian tongue muscles
Origin and development of the avian tongue muscles
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DOI：
10.1007/s004290050268
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发表时间：
1999-08-01
期刊：
影响因子：
--
通讯作者：
Patel, K
中科院分区：
文献类型：
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作者：
Huang, RJ;Zhi, QX;Patel, K
脊椎动物舌头的肌肉系统是由体节募集的细胞组成的。在本文中，我们研究了鸡胚胎发育过程中产生舌肌的肌细胞的迁移和组织。在分子水平上，我们的数据表明，Tbx-3表达细胞的人口迁移远离枕骨体节之前，表达Pax-3的肌肉前体细胞的迁移。这两个群体采取相同的途径，形成舌下神经索。直到细胞从体节迁移了一定距离后，才检测到肌细胞分化的第一个迹象。我们已经确定了单个体节对舌肌肉组织的贡献，并与以前的数据相反，体节2-6在相同程度上参与了所有舌肌和舌骨下肌的形成，但对舌骨上肌没有贡献。这是特别有趣的，因为舌肌和舌骨下肌不同于舌骨上肌不仅在其形态，而且在其发育起源。此外，我们发现，肌细胞跨越中线，并有助于对侧舌肌和舌骨下肌。这是支持我们的分子数据，这表明，迁移的前体人口主要保持在发展中的舌下神经索的喙尖。
The musculature of the vertebrate tongue is composed of cells recruited from the somites. In this paper we have investigated the migration and organisation of the muscle cells that give rise to the tongue muscle during chick embryogenesis. At the molecular level, our data suggests that a population of Tbx-3 expressing cells migrate away from the occipital somites prior to the migration of muscle precursors that express Pax-3. Both populations take the same pathway and form the hypoglossal cord. The first signs of muscle cell differentiation were not detected until cells had migrated some distance from the somites. We have determined the contribution of single somites to the musculature of the tongue and show in contrast to previous data that somites 2-6 take part in the formation of all glossal and infrahyoid muscles to the same extent but do not contribute to suprahyoid muscle. This is particularly interesting since glossal and infrahyoid muscle differ from the suprahyoid muscles not only in their morphology, but also in their developmental origin. Furthermore we show that myocytes cross the midline and contribute to the contralateral glossal and infrahyoid muscles. This is supported from our molecular data, which showed that the migratory precursor population was maintained primarily at the rostral tip of the developing hypoglossal cord.